Lymphoid antigens on blast cells in the agranular metamorphosis of chronic myelogenous leukaemia

Andrea Bacigalupo, G. Santini, G. Piaggio, M. Risso, M. T. Van Lint, M. Carella, E. E. Damasio, M. C. Raffo, A. M. Marmont

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Abstract

Undifferentiated blasts from a Ph'-positive chronic myelogenous leukaemia (CML) in terminal metamorphosis were reacted in an indirect immunofluorescence test with antilymphocytic globulins (AHLGs), raised against cultured lymphoblasts, thoracic duct and peripheral blood lymphocytes from healthy donors. After proper myeloid and/or monocytic absorptions the AHLGs interacted strongly with the undifferentiated blasts of CML, while this was not true for parallel controls with non-lymphoid leukaemias, both acute and chronic. The intensity of fluorescence, as determined by the use of a microfluorimeter, on these agranular blasts was comparable to the positivity of lymphoid cells from acute and chronic lymphatic leukaemias. These findings lend further support to the conception of a lympho-blast-like variety of terminal blastic crisis in chronic myelogenous leukaemia.

Original languageEnglish
Pages (from-to)280-290
Number of pages11
JournalActa Haematologica
Volume60
Issue number5
DOIs
Publication statusPublished - 1978

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Keywords

  • Antilymphocytic globulins
  • Chronic myelogenous leukaemia
  • Leukaemia surface antigens

ASJC Scopus subject areas

  • Hematology

Cite this

Bacigalupo, A., Santini, G., Piaggio, G., Risso, M., Van Lint, M. T., Carella, M., Damasio, E. E., Raffo, M. C., & Marmont, A. M. (1978). Lymphoid antigens on blast cells in the agranular metamorphosis of chronic myelogenous leukaemia. Acta Haematologica, 60(5), 280-290. https://doi.org/10.1159/000207724