Lymphoid chemokines in chronic neuroinflammation

Francesca Aloisi, Sandra Columba-Cabezas, Diego Franciotta, Barbara Rosicarelli, Roberta Magliozzi, Richard Reynolds, Elena Ambrosini, Eliana Coccia, Marco Salvetti, Barbara Serafini

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Lymphoid chemokines play an essential role in the establishment and maintenance of lymphoid tissue microarchitecture and have been implicated in the formation of tertiary (or ectopic) lymphoid tissue in chronic inflammatory conditions. Here, we review recent advances in lymphoid chemokine research in central nervous system inflammation, focusing on multiple sclerosis and the animal model experimental autoimmune encephalomyelitis. We also highlight how the study of lymphoid chemokines, particularly CXCL13, has led to the identification of intrameningeal B-cell follicles in the multiple sclerosis brain paving the way to the discovery that these abnormal structures are highly enriched in Epstein-Barr virus-infected B cells and plasma cells.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalJournal of Neuroimmunology
Volume198
Issue number1-2
DOIs
Publication statusPublished - Jul 31 2008

Fingerprint

Chemokines
Multiple Sclerosis
Chemokine CXCL13
B-Lymphocytes
Autoimmune Experimental Encephalomyelitis
Lymphoid Tissue
Plasma Cells
Human Herpesvirus 4
Central Nervous System
Animal Models
Maintenance
Inflammation
Brain
Research
Tertiary Lymphoid Structures

Keywords

  • Chemokines
  • Epstein-Barr virus
  • Inflammation
  • Lymphoid neogenesis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Aloisi, F., Columba-Cabezas, S., Franciotta, D., Rosicarelli, B., Magliozzi, R., Reynolds, R., ... Serafini, B. (2008). Lymphoid chemokines in chronic neuroinflammation. Journal of Neuroimmunology, 198(1-2), 106-112. https://doi.org/10.1016/j.jneuroim.2008.04.025

Lymphoid chemokines in chronic neuroinflammation. / Aloisi, Francesca; Columba-Cabezas, Sandra; Franciotta, Diego; Rosicarelli, Barbara; Magliozzi, Roberta; Reynolds, Richard; Ambrosini, Elena; Coccia, Eliana; Salvetti, Marco; Serafini, Barbara.

In: Journal of Neuroimmunology, Vol. 198, No. 1-2, 31.07.2008, p. 106-112.

Research output: Contribution to journalArticle

Aloisi, F, Columba-Cabezas, S, Franciotta, D, Rosicarelli, B, Magliozzi, R, Reynolds, R, Ambrosini, E, Coccia, E, Salvetti, M & Serafini, B 2008, 'Lymphoid chemokines in chronic neuroinflammation', Journal of Neuroimmunology, vol. 198, no. 1-2, pp. 106-112. https://doi.org/10.1016/j.jneuroim.2008.04.025
Aloisi F, Columba-Cabezas S, Franciotta D, Rosicarelli B, Magliozzi R, Reynolds R et al. Lymphoid chemokines in chronic neuroinflammation. Journal of Neuroimmunology. 2008 Jul 31;198(1-2):106-112. https://doi.org/10.1016/j.jneuroim.2008.04.025
Aloisi, Francesca ; Columba-Cabezas, Sandra ; Franciotta, Diego ; Rosicarelli, Barbara ; Magliozzi, Roberta ; Reynolds, Richard ; Ambrosini, Elena ; Coccia, Eliana ; Salvetti, Marco ; Serafini, Barbara. / Lymphoid chemokines in chronic neuroinflammation. In: Journal of Neuroimmunology. 2008 ; Vol. 198, No. 1-2. pp. 106-112.
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