Lymphoid chemokines in chronic neuroinflammation

Francesca Aloisi, Sandra Columba-Cabezas, Diego Franciotta, Barbara Rosicarelli, Roberta Magliozzi, Richard Reynolds, Elena Ambrosini, Eliana Coccia, Marco Salvetti, Barbara Serafini

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphoid chemokines play an essential role in the establishment and maintenance of lymphoid tissue microarchitecture and have been implicated in the formation of tertiary (or ectopic) lymphoid tissue in chronic inflammatory conditions. Here, we review recent advances in lymphoid chemokine research in central nervous system inflammation, focusing on multiple sclerosis and the animal model experimental autoimmune encephalomyelitis. We also highlight how the study of lymphoid chemokines, particularly CXCL13, has led to the identification of intrameningeal B-cell follicles in the multiple sclerosis brain paving the way to the discovery that these abnormal structures are highly enriched in Epstein-Barr virus-infected B cells and plasma cells.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalJournal of Neuroimmunology
Volume198
Issue number1-2
DOIs
Publication statusPublished - Jul 31 2008

Keywords

  • Chemokines
  • Epstein-Barr virus
  • Inflammation
  • Lymphoid neogenesis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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