Lymphocytes in cell suspensions and cryostat sections of Warthin's tumors (WT) have been phenotypically characterized using a battery of monoclonal and polyclonal antisera to lymphoid cell-associated antigens. The present study shows that in the WT lymphoid stroma, B cells are more numerous than T lymphocytes and include a significant percentage of surface immunoglobulin A-bearing cells. Of the T cells, the Leu 3a+ and OKT4+ lymphocytes are present in higher percentages than the OKT8+ ones. Both T-cell subsets present a topographic distribution which is similar to that found in human tonsils and gut tunica propria. Intraepithelial lymphocytes displaying an OKT8+, Leu 3a-, OKT3- phenotype are also present. These data, together with previous findings which have demonstrated that Warthin's tumor epithelium synthesizes IgA secretory piece, suggest that these cells may modulate the organization of the surrounding lymphoid stroma toward that of a mature lymphatic tissue phenotypically resembling gut-associated lymphoid tissue.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine