Lymphoid tissue mesenchymal stromal cells in development and tissue remodeling

Luca Genovese, Andrea Brendolan

Research output: Contribution to journalArticle

Abstract

Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.

Original languageEnglish
Article number8419104
JournalStem Cells International
Volume2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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