Abstract
Ig and T(β) gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that ~10% of the cases tested displayed rearrangements of both Ig and T(β) genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
Original language | English |
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Pages (from-to) | 1015-1024 |
Number of pages | 10 |
Journal | Journal of Experimental Medicine |
Volume | 162 |
Issue number | 3 |
Publication status | Published - 1985 |
ASJC Scopus subject areas
- Immunology