Abstract
Ig and T(β) gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that ~10% of the cases tested displayed rearrangements of both Ig and T(β) genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1015-1024 |
| Number of pages | 10 |
| Journal | Journal of Experimental Medicine |
| Volume | 162 |
| Issue number | 3 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Immunology
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Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes. / Pelicci, P. G.; Knowles, D. M.; Dalla Favera, R.
In: Journal of Experimental Medicine, Vol. 162, No. 3, 1985, p. 1015-1024.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes
AU - Pelicci, P. G.
AU - Knowles, D. M.
AU - Dalla Favera, R.
PY - 1985
Y1 - 1985
N2 - Ig and T(β) gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that ~10% of the cases tested displayed rearrangements of both Ig and T(β) genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
AB - Ig and T(β) gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that ~10% of the cases tested displayed rearrangements of both Ig and T(β) genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022388371&partnerID=8YFLogxK
M3 - Article
C2 - 3875679
AN - SCOPUS:0022388371
VL - 162
SP - 1015
EP - 1024
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 3
ER -