Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes

P. G. Pelicci, D. M. Knowles, R. Dalla Favera

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Ig and T(β) gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that ~10% of the cases tested displayed rearrangements of both Ig and T(β) genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.

Original languageEnglish
Pages (from-to)1015-1024
Number of pages10
JournalJournal of Experimental Medicine
Volume162
Issue number3
Publication statusPublished - 1985

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T-Cell Receptor Genes
Immunoglobulins
Immunoglobulin Genes
B-Lymphocytes
T-Lymphocytes
Neoplasms
Gene Rearrangement
Cell Lineage
Surface Antigens
Genetic Markers
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes. / Pelicci, P. G.; Knowles, D. M.; Dalla Favera, R.

In: Journal of Experimental Medicine, Vol. 162, No. 3, 1985, p. 1015-1024.

Research output: Contribution to journalArticle

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