Lymphoma induction by human B cells in scid mice

Alberto Amadori, Maria Luisa Veronese, Maria Rosaria Mazza, Rita Zamarchi, Marta Mion, Emma D'Andrea, Chiara Menin, Annarosa Del Mistro, Anna Leszl, Francesca Calderazzo, Marina Panozzo, Luigi Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review


Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.

Original languageEnglish
Issue numberSUPPL. 3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Cancer Research


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