Lymphomas of the bone: A pathological and clinical study of 54 cases

Umberto Gianelli, Carlo Patriarca, Alessia Moro, Maurilio Ponzoni, Roberto Giardini, Maura Massimino, Rosa Maria Alfano, Elisabetta Armiraglio, Paolo Nuciforo, Silvano Bosari, Guido Coggi, Antonina Parafioriti

Research output: Contribution to journalArticlepeer-review


We examined 28 cases of primary bone lymphomas (PBL; stage IE) and 26 cases of systemic lymphomas involving the bone (SBL; stage IIE to IV). Two histologic types were prevalent: Diffuse large B-cell lymphomas (DLBCL; 26 PBL and 21 SBL) and CD30+ anaplastic large cell lymphomas (ALCL; 1 PBL and 4 SBL). A mature B phenotype (CD45+, CD20+, CD79a+, CDw75+/-, CD10-/+) was established in the DL-BCL group. Bcl-2 immunoreactivity was demonstrated in 13/37 cases (35%), and bcl-6 immunostaining was observed in 22/32 cases (69%). ALCL showed null/T phenotype (CD3-/+; CD43+/-; CD30+), with ALK-1 expression in 3/3 cases. With use of a FR3A primer, a monoclonal pattern was demonstrated by PCR analysis in 22/41 lymphomas (54%). Bcl-2 translocation was identified in 2/41 cases (5%). This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DL-BCL and support their follicle center origin.

Original languageEnglish
Pages (from-to)257-266
Number of pages10
JournalInternational Journal of Surgical Pathology
Issue number4
Publication statusPublished - Oct 2002


  • Anaplastic large cell lymphomas
  • Clonality
  • Diffuse large B-cell lymphomas
  • Immunohistochemistry
  • Non-Hodgkin's lymphomas of bone
  • Primary bone lymphomas

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery


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