Lymphomatoid papulosis (LP) is now considered a T-cell lymphoproliferative disorder of low-grade malignancy. LP is characterized by self-healing papulonodular lesions, with remissions that may last months or years. In approximately 5% of LP patients, progression to malignant lymphoma is described. In this study, we retrospectively investigated 7 cases of LP, reporting their clinical aspects and course, and evaluating histological and immunophenotypical features of the cellular infiltrate. Age at diagnosis ranged between 3 and 80 years, and during the observation period (variable between 14 months and 16 years) in none of the patients was demonstrated an evolution into a malignant lymphoma. Histologically, in 3 cases with longer disease duration, we observed numerous eosinophils besides the 'atypical' lymphoid cells in the infiltrate. The atypical cells showed CD3-, CD4-, HLA-DR- and CD30-positivity, while other lymphocyte activation-related markers (CD71, CD25) were incostantly expressed. We suggest that the presence of numerous eosinophils in the infiltrate might be associated with a longer disease duration and a reduced risk of evolution into a malignant lymphoma.
|Translated title of the contribution||Lymphomatoid papulosis. A clinical, histological and immunohistochemical study of 7 cases|
|Number of pages||8|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1994|
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