Lymphomononuclear cells from multiple sclerosis patients spontaneously produce high levels of oncostatin M, tumor necrosis factors α and β and interferon γ

F. Ensoli, V. Fiorelli, A. Lugaresi, D. Farina, M. De Cristofaro, B. Collacchi, D. Santini Muratori, E. Scala, M. Di Gioacchino, R. Paganelli, F. Aiuti

Research output: Contribution to journalArticle

Abstract

Proinflammatory cytokines are deemed to play a pivotal role in the pathogenesis of multiple sclerosis (MS). They provide signals for T-cell activation and inflammatory cell recruitment in the brain and might directly alter neuroglial and neuronal cell survival and function. We found that peripheral blood mononuclear cells (PBMCs) from MS patients spontaneously produce high levels of TNFα, TNFβ, IFNγ, and oncostatin M (oncM), a proinflammatory cytokine acting on cells of neural, vascular, hematopoietic, and lymphoid origin. Spontaneous production of these cytokines was significantly higher (p

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalMultiple Sclerosis Journal
Volume8
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Cell cultures
  • Cytokines
  • Demyelinating diseases
  • ELISA
  • Interferon
  • Mononuclear cells
  • Multiple sclerosis
  • Oncostatin M

ASJC Scopus subject areas

  • Clinical Neurology

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    Ensoli, F., Fiorelli, V., Lugaresi, A., Farina, D., De Cristofaro, M., Collacchi, B., Santini Muratori, D., Scala, E., Di Gioacchino, M., Paganelli, R., & Aiuti, F. (2002). Lymphomononuclear cells from multiple sclerosis patients spontaneously produce high levels of oncostatin M, tumor necrosis factors α and β and interferon γ. Multiple Sclerosis Journal, 8(4), 284-288. https://doi.org/10.1191/1352458502ms817oa