Lymphopenia and decrease in the total number of circulating CD3+ and CD4+ T cells during ‘long-term’ PUVA treatment for psoriasis

Giovanni Borroni, C. Zaccone, G. Vignati, A. Fietta, M. Gatti, V. Brazzelli, G. Rabbiosi

Research output: Contribution to journalArticle

Abstract

The relationship between high-dose PUVA treatment in psoriatic patients and peripheral T lymphocyte subsets (total number and percentage) has been studied. Of the two groups of patients considered, the first included 19 patients, all affected by chronic, progressively worsening psoriasis; they had never been previously treated by photochemotherapy. The second group included 13 psoriatic patients, who had received an average cumulative dose of 2,007.69 ± 1,191.05 J/cm2. The ‘long-term’ PUVA-treated group was assessed while undergoing maintenance therapy. No significant differences were found between untreated patients and healthy controls for any of the parameters considered. A significant reduction (p

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalDermatology
Volume183
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • Lymphopenia
  • Peripheral blood
  • Psoriasis
  • PUVA treatment
  • T lymphocyte subset impairment

ASJC Scopus subject areas

  • Dermatology

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