Un'attività sierica che stimola la linfoproliferazione.

Translated title of the contribution: Lymphoproliferation stimulating activity in serum

A. Moretta, A. Valtorta, I. Biscaldi, A. Fiori

Research output: Contribution to journalArticle

Abstract

To characterize the serum growth promoting activity estimated by means of bioassay (Thymidine Activity), the gel filtration chromatographic profile of sera obtained from 10 normal adults and from 10 normal infants was performed. For each serum fraction we evaluated the capacity to stimulate the tritiated thymidine (3H-TdR) uptake into lectin-activated lymphocytes. This capacity was expressed as percent increase in 3H-TdR uptake in presence and in absence of the optimal dose (1.25%) of the fraction. The highest percent increase in 3H-TdR uptake was obtained in the same three fractions (1500-2500 Kd, 28-42 Kd, 1.3-1.9 Kd) in the sera of adults as well as infants. The values observed in infants were higher than in adults, suggesting that the serum growth-promoting activity could be higher in rapidly growing subjects.

Original languageItalian
Pages (from-to)146-148
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number2
Publication statusPublished - Apr 1990

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Serum
Thymidine
Lectins
Biological Assay
Gel Chromatography
Lymphocytes
growth promoting activity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Un'attività sierica che stimola la linfoproliferazione. / Moretta, A.; Valtorta, A.; Biscaldi, I.; Fiori, A.

In: Medicina - Rivista della Enciclopedia Medica Italiana, Vol. 10, No. 2, 04.1990, p. 146-148.

Research output: Contribution to journalArticle

Moretta, A. ; Valtorta, A. ; Biscaldi, I. ; Fiori, A. / Un'attività sierica che stimola la linfoproliferazione. In: Medicina - Rivista della Enciclopedia Medica Italiana. 1990 ; Vol. 10, No. 2. pp. 146-148.
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