TY - JOUR
T1 - Lynch syndrome-related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types
AU - Carcangiu, Maria Luisa
AU - Radice, Paolo
AU - Casalini, Patrizia
AU - Bertario, Lucio
AU - Merola, Marina
AU - Sala, Paolo
PY - 2010/2
Y1 - 2010/2
N2 - Although endometrial cancer (EC) represents the second most common cancer after colonic cancer in patients with Lynch syndrome (LS), the pathologic features and behavior of LS-related EC are not well recognized. ECs from 23 patients (mean age 46.2 years) with MSH2 (16), MLH1 (6), and MLH1/MSH2 (1) constitutional mutations were evaluated for histologic type, FIGO grade, FIGO stage, association with tumors in other sites, and survival. For every LS-associated tumor, 2 same-age cases from patients with no family history of LS-associated cancer were evaluated (sporadic group). In LS-associated EC there were 13 (56.5%) endometrioid (eec) and 10 (43.5%) nonendometrioid carcinomas (neec), and among the sporadic tumors there were 44 (95.7%) eec and 2 (4.3%) neec (P =.001). The eec in women with germline LS mutation had a significantly higher FIGO grade (P =.0378) and more frequent vascular invasion than the controls. The mean survival of the entire group of 23 patients with LS-related EC was 17.326 (14.066 to 20.585). Mean survival according to FIGO stage was significant (P =.010). Difference in mean survival according to age of the patient at the time of the diagnosis (patients >46 years vs
AB - Although endometrial cancer (EC) represents the second most common cancer after colonic cancer in patients with Lynch syndrome (LS), the pathologic features and behavior of LS-related EC are not well recognized. ECs from 23 patients (mean age 46.2 years) with MSH2 (16), MLH1 (6), and MLH1/MSH2 (1) constitutional mutations were evaluated for histologic type, FIGO grade, FIGO stage, association with tumors in other sites, and survival. For every LS-associated tumor, 2 same-age cases from patients with no family history of LS-associated cancer were evaluated (sporadic group). In LS-associated EC there were 13 (56.5%) endometrioid (eec) and 10 (43.5%) nonendometrioid carcinomas (neec), and among the sporadic tumors there were 44 (95.7%) eec and 2 (4.3%) neec (P =.001). The eec in women with germline LS mutation had a significantly higher FIGO grade (P =.0378) and more frequent vascular invasion than the controls. The mean survival of the entire group of 23 patients with LS-related EC was 17.326 (14.066 to 20.585). Mean survival according to FIGO stage was significant (P =.010). Difference in mean survival according to age of the patient at the time of the diagnosis (patients >46 years vs
KW - Endometrial carcinoma
KW - Histologic types
KW - Lynch syndrome
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U2 - 10.1177/1066896909332117
DO - 10.1177/1066896909332117
M3 - Article
C2 - 19443869
AN - SCOPUS:76649130529
VL - 18
SP - 21
EP - 26
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 1
ER -