Lynch syndrome-related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types

Maria Luisa Carcangiu, Paolo Radice, Patrizia Casalini, Lucio Bertario, Marina Merola, Paolo Sala

Research output: Contribution to journalArticlepeer-review

Abstract

Although endometrial cancer (EC) represents the second most common cancer after colonic cancer in patients with Lynch syndrome (LS), the pathologic features and behavior of LS-related EC are not well recognized. ECs from 23 patients (mean age 46.2 years) with MSH2 (16), MLH1 (6), and MLH1/MSH2 (1) constitutional mutations were evaluated for histologic type, FIGO grade, FIGO stage, association with tumors in other sites, and survival. For every LS-associated tumor, 2 same-age cases from patients with no family history of LS-associated cancer were evaluated (sporadic group). In LS-associated EC there were 13 (56.5%) endometrioid (eec) and 10 (43.5%) nonendometrioid carcinomas (neec), and among the sporadic tumors there were 44 (95.7%) eec and 2 (4.3%) neec (P =.001). The eec in women with germline LS mutation had a significantly higher FIGO grade (P =.0378) and more frequent vascular invasion than the controls. The mean survival of the entire group of 23 patients with LS-related EC was 17.326 (14.066 to 20.585). Mean survival according to FIGO stage was significant (P =.010). Difference in mean survival according to age of the patient at the time of the diagnosis (patients >46 years vs

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Endometrial carcinoma
  • Histologic types
  • Lynch syndrome

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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