Lysosomal changes and enterocytic copper deposits in wilson’s disease

Giovanni Gasbarrini, G. R. Corazza, F. Bonvicini

Research output: Contribution to journalArticlepeer-review


In 4 siblings, of whom 2 had symptoms of Wilson’s disease, electron microscopy showed that the number and size of lysosomes in the enterocytes were increased compared with controls. Electron-dense aggregates, observed near the lysosomes in the 2 symptomatic patients and 1 other sibling, were shown, by means of a microanalytical method, to contain copper. These findings could suggest a possible role of the small intestine in Wilson’s disease.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
Issue number5
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Gastroenterology


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