Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Chiara Balducci, Laura Pierguidi, Emanuele Persichetti, Lucilla Parnetti, Michele Sbaragli, Carmelo Tassi, Aldo Orlacchio, Paolo Calabresi, Tommaso Beccari, Aroldo Rossi

Research output: Contribution to journalArticle

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of P-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of pVgalactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

Original languageEnglish
Pages (from-to)1481-1484
Number of pages4
JournalMovement Disorders
Volume22
Issue number10
DOIs
Publication statusPublished - Jul 30 2007

Keywords

  • α-mannosidase
  • β-glucocerebrosidase
  • β-hexosaminidase
  • β-mannosidase
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Balducci, C., Pierguidi, L., Persichetti, E., Parnetti, L., Sbaragli, M., Tassi, C., Orlacchio, A., Calabresi, P., Beccari, T., & Rossi, A. (2007). Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease. Movement Disorders, 22(10), 1481-1484. https://doi.org/10.1002/mds.21399