Abstract
NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 21-27 |
| Number of pages | 7 |
| Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
| Volume | 72 |
| Issue number | 1-2 |
| Publication status | Published - Jan 1996 |
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Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line. / Mariani, E.; Tarozzi, A.; Meneghetti, A.; Tadolini, M.; Facchini, A.
In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 72, No. 1-2, 01.1996, p. 21-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.
AU - Mariani, E.
AU - Tarozzi, A.
AU - Meneghetti, A.
AU - Tadolini, M.
AU - Facchini, A.
PY - 1996/1
Y1 - 1996/1
N2 - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.
AB - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=0029684114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029684114&partnerID=8YFLogxK
M3 - Article
C2 - 8868111
AN - SCOPUS:0029684114
VL - 72
SP - 21
EP - 27
JO - Bollettino della Societa Italiana di Biologia Sperimentale
JF - Bollettino della Societa Italiana di Biologia Sperimentale
SN - 0037-8771
IS - 1-2
ER -