Abstract
NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.
Original language | English |
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Pages (from-to) | 21-27 |
Number of pages | 7 |
Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
Volume | 72 |
Issue number | 1-2 |
Publication status | Published - Jan 1996 |