Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

E. Mariani, A. Tarozzi, A. Meneghetti, M. Tadolini, A. Facchini

Research output: Contribution to journalArticlepeer-review

Abstract

NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume72
Issue number1-2
Publication statusPublished - Jan 1996

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