Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

E. Mariani; A. Tarozzi; A. Meneghetti; M. Tadolini; A. Facchini

Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

E. Mariani, A. Tarozzi, A. Meneghetti, M. Tadolini, A. Facchini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	72
Issue number	1-2
Publication status	Published - Jan 1996

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title = "Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.",

abstract = "NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.",

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AU - Tarozzi, A.

AU - Meneghetti, A.

AU - Tadolini, M.

AU - Facchini, A.

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N2 - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

AB - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

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Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

Abstract

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