Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

E. Mariani, A. Tarozzi, A. Meneghetti, M. Tadolini, A. Facchini

Research output: Contribution to journalArticle

Abstract

NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume72
Issue number1-2
Publication statusPublished - Jan 1996

Fingerprint

Osteosarcoma
Interleukin-12
Natural Killer Cells
Interleukin-2
Cell Line
Oncogenic Viruses
K562 Cells
Human Activities
Lymphocytes

Cite this

Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line. / Mariani, E.; Tarozzi, A.; Meneghetti, A.; Tadolini, M.; Facchini, A.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 72, No. 1-2, 01.1996, p. 21-27.

Research output: Contribution to journalArticle

Mariani, E. ; Tarozzi, A. ; Meneghetti, A. ; Tadolini, M. ; Facchini, A. / Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line. In: Bollettino della Societa Italiana di Biologia Sperimentale. 1996 ; Vol. 72, No. 1-2. pp. 21-27.
@article{4672d04ad4b648e59bbd2be234d29d5a,
title = "Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.",
abstract = "NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.",
author = "E. Mariani and A. Tarozzi and A. Meneghetti and M. Tadolini and A. Facchini",
year = "1996",
month = "1",
language = "English",
volume = "72",
pages = "21--27",
journal = "Bollettino della Societa Italiana di Biologia Sperimentale",
issn = "0037-8771",
publisher = "Casa Editrice Idelson Gnocchi",
number = "1-2",

}

TY - JOUR

T1 - Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.

AU - Mariani, E.

AU - Tarozzi, A.

AU - Meneghetti, A.

AU - Tadolini, M.

AU - Facchini, A.

PY - 1996/1

Y1 - 1996/1

N2 - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

AB - NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0029684114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029684114&partnerID=8YFLogxK

M3 - Article

C2 - 8868111

AN - SCOPUS:0029684114

VL - 72

SP - 21

EP - 27

JO - Bollettino della Societa Italiana di Biologia Sperimentale

JF - Bollettino della Societa Italiana di Biologia Sperimentale

SN - 0037-8771

IS - 1-2

ER -