Abstract
The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.
| Original language | English |
|---|---|
| Pages (from-to) | 477-478 |
| Number of pages | 2 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 33 |
| Issue number | 7 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. / Caccia, S.; Ballabio, M.; Samanin, R.; Zanini, M. G.; Garattini, S.
In: Journal of Pharmacy and Pharmacology, Vol. 33, No. 7, 1981, p. 477-478.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - (-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone
AU - Caccia, S.
AU - Ballabio, M.
AU - Samanin, R.
AU - Zanini, M. G.
AU - Garattini, S.
PY - 1981
Y1 - 1981
N2 - The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.
AB - The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.
UR - http://www.scopus.com/inward/record.url?scp=0019859218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019859218&partnerID=8YFLogxK
M3 - Article
VL - 33
SP - 477
EP - 478
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 7
ER -