(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

S. Caccia, M. Ballabio, R. Samanin, M. G. Zanini, S. Garattini

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Abstract

The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.

Original languageEnglish
Pages (from-to)477-478
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume33
Issue number7
Publication statusPublished - 1981

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Trazodone
Serotonin Receptor Agonists
Serotonin
Brain
Oral Administration
piperazine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. / Caccia, S.; Ballabio, M.; Samanin, R.; Zanini, M. G.; Garattini, S.

In: Journal of Pharmacy and Pharmacology, Vol. 33, No. 7, 1981, p. 477-478.

Research output: Contribution to journalArticle

Caccia, S. ; Ballabio, M. ; Samanin, R. ; Zanini, M. G. ; Garattini, S. / (-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. In: Journal of Pharmacy and Pharmacology. 1981 ; Vol. 33, No. 7. pp. 477-478.
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