(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

S. Caccia; M. Ballabio; R. Samanin; M. G. Zanini; S. Garattini

(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

S. Caccia, M. Ballabio, R. Samanin, M. G. Zanini, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.

Original language	English
Pages (from-to)	477-478
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	33
Issue number	7
Publication status	Published - 1981

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

Fingerprint Dive into the research topics of '(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone'. Together they form a unique fingerprint.

Cite this

@article{abee382c09c14c2ebf4af8ee340712bd,

title = "(-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone",

abstract = "The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.",

author = "S. Caccia and M. Ballabio and R. Samanin and Zanini, {M. G.} and S. Garattini",

year = "1981",

language = "English",

volume = "33",

pages = "477--478",

journal = "Journal of Pharmacy and Pharmacology",

issn = "0022-3573",

publisher = "Pharmaceutical Press",

number = "7",

}

TY - JOUR

T1 - (-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

AU - Caccia, S.

AU - Ballabio, M.

AU - Samanin, R.

AU - Zanini, M. G.

AU - Garattini, S.

PY - 1981

Y1 - 1981

N2 - The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.

AB - The aim of the present study was to prove that substantial amounts of mCPP are formed in the brain after oral administration of trazodone. To obtain preliminary information on the significance of mCPP formation for the effects of trazodone, brain levels of mCPP in rats treated with trazodone were compared with those found after pharmacologically and biochemically effective doses of mCPP. These results confirm the suggestion that mCPP may play an important role in the 5-HT-agonistic effects of relatively high doses of trazodone in the rat. Whether this is also true for the anti-5-HT effects found after low doses of trazodone remains to be clarified.

UR - http://www.scopus.com/inward/record.url?scp=0019859218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019859218&partnerID=8YFLogxK

M3 - Article

C2 - 6115042

AN - SCOPUS:0019859218

VL - 33

SP - 477

EP - 478

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 7

ER -