m-Chlorophenylpiperazine

A central serotonin agonist causing powerful anorexia in rats

R. Samanin, T. Mennini, A. Ferraris, C. Bendotti, F. Borsini, S. Garattini

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Meta-chlorophenylpiperazine inhibited serotonin and noradrenaline uptake by synaptosomes to the same extent with IC50 of 1.3×10-6 M and 5.8×10-6 M respectively. Dopamine uptake was lesss affected by meta-chlorophenylpiperazine (IC50 of 2.2×10-5 M). Unlike d-amphetamine and d-fenfluramine, the drug did not significantly increase monoamine release in synaptosomal preparations. On the other hand, metachlorophenylpiperazine showed an IC50 of 620 nM in displacing 3H-5HT binding to brain membranes. Meta-chlorophenylpiperazine produced a dose-dependent reduction of food intake and this effect was prevented by a pretreatment with methergoline, a serotonin antagonist. The effect of metachlorophenylpiperazine was not modified by an intraventricular injection of 6-hydroxydopamine, electrolytic lesions of nucleus medianus raphe or ventral noradrenergic bundle, nor by a pretreatment with penfluridol, propranolol or phentolamine. The data suggest that the decrease of food intake induced by metachlorophenylpiperazine depends on its ability to act as a serotonin agonist in the brain. The specificity of the effects on serotonin suggests that this compound could prove an important tool for studies aimed at elucidating the functional role of serotonin in the central nervous system.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume308
Issue number2
DOIs
Publication statusPublished - Aug 1979

Fingerprint

Serotonin Receptor Agonists
Anorexia
Inhibitory Concentration 50
Serotonin
Penfluridol
Eating
Metergoline
Intraventricular Injections
Fenfluramine
Dextroamphetamine
Serotonin Antagonists
Raphe Nuclei
Synaptosomes
Phentolamine
Oxidopamine
Brain
Propranolol
Dopamine
Norepinephrine
Central Nervous System

Keywords

  • Anorexia
  • Catecholamines
  • Metachlorophenylpiperazine
  • Receptor stimulation
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

m-Chlorophenylpiperazine : A central serotonin agonist causing powerful anorexia in rats. / Samanin, R.; Mennini, T.; Ferraris, A.; Bendotti, C.; Borsini, F.; Garattini, S.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 308, No. 2, 08.1979, p. 159-163.

Research output: Contribution to journalArticle

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