Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development

M. Mariani, A. Corradi, D. Baldessari, N. Malgaretti, O. Pozzoli, R. Fesce, S. Martinez, E. Boncinelli, G. G. Consalez

Research output: Contribution to journalArticlepeer-review

Abstract

A multitude of regulatory genes are involved in phylogenetically conserved developmental cascades required for the patterning, cell-type specification, and differentiation of specific central nervous system (CNS) structures. Here, we describe the distribution of a mouse transcript encoding a homolog of the C. elegans mab-21 gene. In the nematode tail, mab-21 is required for the short-range patterning and cell-fate determination events mediated by egl-5 and mab-18, two homeobox genes homologous to Abd-B and Pax6, respectively. In mouse midgestation embryogenesis, Mab21 is expressed at its highest levels in the rhombencephalon, cerebellum, midbrain, and prospective neural retina. Our data and the genetic interactions previously documented in the nematode suggest that Mab21 may represent a novel, important regulator of mammalian cerebellum and eye development.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalMechanisms of Development
Volume79
Issue number1-2
DOIs
Publication statusPublished - 1998

Keywords

  • Cell type specification
  • Cerebellar development
  • Eye development
  • mab- 21
  • Mab21
  • Midbrain development

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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