Macroamylasemia in a patient with multiple myeloma

Marco Sagristani, Roberto Guariglia, Barbara Pocali, Mafalda De Rienzo, Salvatore Guastafierro, Gaetano Romano, Angelo Tirelli

Research output: Contribution to journalArticle


We report a rare case of a patient with multiple myeloma who developed hyperamylasemia not associated to hyperamylasuria and without symptoms of pancreatic or salivary disease. This condition suggested the occurrence of macroamylasemia, consisting of macromolecules of amylase bound with immunoglobulins, which are not filtered by the kidneys. Hyperamylasemia was not present at the diagnosis of myeloma and appeared at the relapse of the disease, simultaneously with the appearance of an additional γ-chain oligoclonal component, suggesting a possible role of these chains in producing macroamylasemia. To our knowledge, this is the first report of macroamylasemia in a patient with multiple myeloma.

Original languageEnglish
Pages (from-to)1705-1707
Number of pages3
JournalLeukemia and Lymphoma
Issue number8
Publication statusPublished - 2002



  • Benign hyperamylasemia
  • Macroamylasemia
  • Multiple myeloma
  • Oligoclonal component

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Sagristani, M., Guariglia, R., Pocali, B., De Rienzo, M., Guastafierro, S., Romano, G., & Tirelli, A. (2002). Macroamylasemia in a patient with multiple myeloma. Leukemia and Lymphoma, 43(8), 1705-1707.