Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study

Anne Claire Vergnaud, Teresa Norat, Traci Mouw, Dora Romaguera, Anne M. May, H. Bas Bueno-de-Mesquita, Daphne van der A, Antonio Agudo, Nicholas Wareham, Kay Tee Khaw, Isabelle Romieu, Heinz Freisling, Nadia Slimani, Florence Perquier, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Domenico Palli, Franco Berrino, Amalia Mattiello, Rosario Tumino & 27 others Fulvio Ricceri, Laudina Rodríguez, Esther Molina-Montes, Pilar Amiano, Aurelio Barricarte, Maria Dolores Chirlaque, Francesca L. Crowe, Philippos Orfanos, Androniki Naska, Antonia Trichopoulou, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Brian Buijsse, Ingeged Johansson, Göran Hallmans, Isabel Drake, Emily Sonestedt, Marianne Uhre Jakobsen, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Guri Skeie, Tonje Braaten, Eiliv Lund, Elio Riboli, Petra H M Peeters

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index. Results: A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants ≥60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline. Conclusion: Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.

Original languageEnglish
Article numbere57300
JournalPLoS One
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 5 2013

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Nutrition
Diet
Weights and Measures
energy
Chemical analysis
diet
Proteins
Carbohydrates
Weight Gain
carbohydrates
proteins
Fats
Association reactions
weight gain
Energy Intake
weight control
lipids
protein intake
eating habits
Linear Models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Vergnaud, A. C., Norat, T., Mouw, T., Romaguera, D., May, A. M., Bueno-de-Mesquita, H. B., ... Peeters, P. H. M. (2013). Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study. PLoS One, 8(3), [e57300]. https://doi.org/10.1371/journal.pone.0057300

Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study. / Vergnaud, Anne Claire; Norat, Teresa; Mouw, Traci; Romaguera, Dora; May, Anne M.; Bueno-de-Mesquita, H. Bas; van der A, Daphne; Agudo, Antonio; Wareham, Nicholas; Khaw, Kay Tee; Romieu, Isabelle; Freisling, Heinz; Slimani, Nadia; Perquier, Florence; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Palli, Domenico; Berrino, Franco; Mattiello, Amalia; Tumino, Rosario; Ricceri, Fulvio; Rodríguez, Laudina; Molina-Montes, Esther; Amiano, Pilar; Barricarte, Aurelio; Chirlaque, Maria Dolores; Crowe, Francesca L.; Orfanos, Philippos; Naska, Androniki; Trichopoulou, Antonia; Teucher, Birgit; Kaaks, Rudolf; Boeing, Heiner; Buijsse, Brian; Johansson, Ingeged; Hallmans, Göran; Drake, Isabel; Sonestedt, Emily; Jakobsen, Marianne Uhre; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Skeie, Guri; Braaten, Tonje; Lund, Eiliv; Riboli, Elio; Peeters, Petra H M.

In: PLoS One, Vol. 8, No. 3, e57300, 05.03.2013.

Research output: Contribution to journalArticle

Vergnaud, AC, Norat, T, Mouw, T, Romaguera, D, May, AM, Bueno-de-Mesquita, HB, van der A, D, Agudo, A, Wareham, N, Khaw, KT, Romieu, I, Freisling, H, Slimani, N, Perquier, F, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, D, Berrino, F, Mattiello, A, Tumino, R, Ricceri, F, Rodríguez, L, Molina-Montes, E, Amiano, P, Barricarte, A, Chirlaque, MD, Crowe, FL, Orfanos, P, Naska, A, Trichopoulou, A, Teucher, B, Kaaks, R, Boeing, H, Buijsse, B, Johansson, I, Hallmans, G, Drake, I, Sonestedt, E, Jakobsen, MU, Overvad, K, Tjønneland, A, Halkjær, J, Skeie, G, Braaten, T, Lund, E, Riboli, E & Peeters, PHM 2013, 'Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study', PLoS One, vol. 8, no. 3, e57300. https://doi.org/10.1371/journal.pone.0057300
Vergnaud AC, Norat T, Mouw T, Romaguera D, May AM, Bueno-de-Mesquita HB et al. Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study. PLoS One. 2013 Mar 5;8(3). e57300. https://doi.org/10.1371/journal.pone.0057300
Vergnaud, Anne Claire ; Norat, Teresa ; Mouw, Traci ; Romaguera, Dora ; May, Anne M. ; Bueno-de-Mesquita, H. Bas ; van der A, Daphne ; Agudo, Antonio ; Wareham, Nicholas ; Khaw, Kay Tee ; Romieu, Isabelle ; Freisling, Heinz ; Slimani, Nadia ; Perquier, Florence ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Palli, Domenico ; Berrino, Franco ; Mattiello, Amalia ; Tumino, Rosario ; Ricceri, Fulvio ; Rodríguez, Laudina ; Molina-Montes, Esther ; Amiano, Pilar ; Barricarte, Aurelio ; Chirlaque, Maria Dolores ; Crowe, Francesca L. ; Orfanos, Philippos ; Naska, Androniki ; Trichopoulou, Antonia ; Teucher, Birgit ; Kaaks, Rudolf ; Boeing, Heiner ; Buijsse, Brian ; Johansson, Ingeged ; Hallmans, Göran ; Drake, Isabel ; Sonestedt, Emily ; Jakobsen, Marianne Uhre ; Overvad, Kim ; Tjønneland, Anne ; Halkjær, Jytte ; Skeie, Guri ; Braaten, Tonje ; Lund, Eiliv ; Riboli, Elio ; Peeters, Petra H M. / Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study. In: PLoS One. 2013 ; Vol. 8, No. 3.
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abstract = "Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5{\%} of energy from one macronutrient by 5{\%} of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index. Results: A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants ≥60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14{\%} of energy from protein, diets with more than 22{\%} of energy from protein were associated with a 23-24{\%} higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline. Conclusion: Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.",
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AU - Vergnaud, Anne Claire

AU - Norat, Teresa

AU - Mouw, Traci

AU - Romaguera, Dora

AU - May, Anne M.

AU - Bueno-de-Mesquita, H. Bas

AU - van der A, Daphne

AU - Agudo, Antonio

AU - Wareham, Nicholas

AU - Khaw, Kay Tee

AU - Romieu, Isabelle

AU - Freisling, Heinz

AU - Slimani, Nadia

AU - Perquier, Florence

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Palli, Domenico

AU - Berrino, Franco

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Rodríguez, Laudina

AU - Molina-Montes, Esther

AU - Amiano, Pilar

AU - Barricarte, Aurelio

AU - Chirlaque, Maria Dolores

AU - Crowe, Francesca L.

AU - Orfanos, Philippos

AU - Naska, Androniki

AU - Trichopoulou, Antonia

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Buijsse, Brian

AU - Johansson, Ingeged

AU - Hallmans, Göran

AU - Drake, Isabel

AU - Sonestedt, Emily

AU - Jakobsen, Marianne Uhre

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Skeie, Guri

AU - Braaten, Tonje

AU - Lund, Eiliv

AU - Riboli, Elio

AU - Peeters, Petra H M

PY - 2013/3/5

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