Macronutrient intake and risk of colorectal cancer in Italy

Silvia Francescht, Carlo La Vecchia, Antonio Russo, Adriano Favero, Eva Negri, Ettore Conti, Maurizio Montella, Rosa Filiberti, Amadori Dino, Adriano Decarli

Research output: Contribution to journalArticlepeer-review


To provide further insight on the relationship between macronutrients and colorectal cancer, overall and by specific subsite(s), we carried out between 1992 and 1996 in 6 Italian areas a case-control study on 1,953 individuals of both sexes with incident colorectal cancer (age range 19-74) and 4,154 controls (age range 19-74) in hospital with acute, nonneoplastic diseases. A validated food-frequency questionnaire was used, including questions on 78 foods or recipes and on individual fat-intake pattern. The risk of cancer of the colon and rectum increased with total energy intake (odds ratio in highest vs. lowest quintile 1.43 and 1.50, respectively). The risk also rose significantly with an increase of starch intake, whereas it moderately decreased with an increase of protein intake. Monounsaturated fat intake appeared uninfluential, while saturated fat intake showed a modest direct association with rectal cancer. Polyunsaturated fat intake was inversely associated with colon cancer risk, particularly with the right colon.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Macronutrient intake and risk of colorectal cancer in Italy'. Together they form a unique fingerprint.

Cite this