Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Naomi E. Allen, Paul N. Appleby, Timothy J. Key, H. B. Bueno-De-Mesquita, Martine M. Ros, Lambertus A L M Kiemeney, Anne Tjønneland, Nina Roswall, Kim Overvad, Steffen Weikert, Heiner Boeing, Jenny Chang-Claude, Birgit Teucher, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Sabina Sieri, Petra Peeters, Jose Ramón Quirós & 22 others Paula Jakszyn, Esther Molina-Montes, María Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Kay Tee Khaw, Nick Wareham, Börje Ljungberg, Göran Hallmans, Roy Ehrnström, Ulrika Ericson, Inger Torhild Gram, Christine L. Parr, Antonia Trichopoulou, Tina Karapetyan, Vardis Dilis, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Guy Fagherrazzi, Isabelle Romieu, Marc J. Gunter, Elio Riboli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3-30%; p trend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36-7%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.

Original languageEnglish
Pages (from-to)635-644
Number of pages10
JournalInternational Journal of Cancer
Volume132
Issue number3
DOIs
Publication statusPublished - Feb 1 2013

Fingerprint

Carcinoma
Plant Proteins
Neoplasms
Energy Intake
Confidence Intervals
Dietary Fats
Urinary Bladder Neoplasms
Body Mass Index
Smoking
Carbohydrates
Calcium
Proteins

Keywords

  • bladder cancer
  • cohort studies
  • diet
  • epidemiology
  • nutrients

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Allen, N. E., Appleby, P. N., Key, T. J., Bueno-De-Mesquita, H. B., Ros, M. M., Kiemeney, L. A. L. M., ... Riboli, E. (2013). Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition. International Journal of Cancer, 132(3), 635-644. https://doi.org/10.1002/ijc.27643

Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition. / Allen, Naomi E.; Appleby, Paul N.; Key, Timothy J.; Bueno-De-Mesquita, H. B.; Ros, Martine M.; Kiemeney, Lambertus A L M; Tjønneland, Anne; Roswall, Nina; Overvad, Kim; Weikert, Steffen; Boeing, Heiner; Chang-Claude, Jenny; Teucher, Birgit; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Sieri, Sabina; Peeters, Petra; Quirós, Jose Ramón; Jakszyn, Paula; Molina-Montes, Esther; Chirlaque, María Dolores; Ardanaz, Eva; Dorronsoro, Miren; Khaw, Kay Tee; Wareham, Nick; Ljungberg, Börje; Hallmans, Göran; Ehrnström, Roy; Ericson, Ulrika; Gram, Inger Torhild; Parr, Christine L.; Trichopoulou, Antonia; Karapetyan, Tina; Dilis, Vardis; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Fagherrazzi, Guy; Romieu, Isabelle; Gunter, Marc J.; Riboli, Elio.

In: International Journal of Cancer, Vol. 132, No. 3, 01.02.2013, p. 635-644.

Research output: Contribution to journalArticle

Allen, NE, Appleby, PN, Key, TJ, Bueno-De-Mesquita, HB, Ros, MM, Kiemeney, LALM, Tjønneland, A, Roswall, N, Overvad, K, Weikert, S, Boeing, H, Chang-Claude, J, Teucher, B, Panico, S, Sacerdote, C, Tumino, R, Palli, D, Sieri, S, Peeters, P, Quirós, JR, Jakszyn, P, Molina-Montes, E, Chirlaque, MD, Ardanaz, E, Dorronsoro, M, Khaw, KT, Wareham, N, Ljungberg, B, Hallmans, G, Ehrnström, R, Ericson, U, Gram, IT, Parr, CL, Trichopoulou, A, Karapetyan, T, Dilis, V, Clavel-Chapelon, F, Boutron-Ruault, MC, Fagherrazzi, G, Romieu, I, Gunter, MJ & Riboli, E 2013, 'Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition', International Journal of Cancer, vol. 132, no. 3, pp. 635-644. https://doi.org/10.1002/ijc.27643
Allen, Naomi E. ; Appleby, Paul N. ; Key, Timothy J. ; Bueno-De-Mesquita, H. B. ; Ros, Martine M. ; Kiemeney, Lambertus A L M ; Tjønneland, Anne ; Roswall, Nina ; Overvad, Kim ; Weikert, Steffen ; Boeing, Heiner ; Chang-Claude, Jenny ; Teucher, Birgit ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Palli, Domenico ; Sieri, Sabina ; Peeters, Petra ; Quirós, Jose Ramón ; Jakszyn, Paula ; Molina-Montes, Esther ; Chirlaque, María Dolores ; Ardanaz, Eva ; Dorronsoro, Miren ; Khaw, Kay Tee ; Wareham, Nick ; Ljungberg, Börje ; Hallmans, Göran ; Ehrnström, Roy ; Ericson, Ulrika ; Gram, Inger Torhild ; Parr, Christine L. ; Trichopoulou, Antonia ; Karapetyan, Tina ; Dilis, Vardis ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Fagherrazzi, Guy ; Romieu, Isabelle ; Gunter, Marc J. ; Riboli, Elio. / Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition. In: International Journal of Cancer. 2013 ; Vol. 132, No. 3. pp. 635-644.
@article{55001fd37313480d8a3c50761d1293b9,
title = "Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition",
abstract = "Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3{\%} increase in the consumption of energy intake from animal protein was associated with a 15{\%} higher risk (95{\%} confidence interval [CI]: 3-30{\%}; p trend = 0.01) and a 2{\%} increase in energy from plant protein intake was associated with a 23{\%} lower risk (95{\%} CI: 36-7{\%}, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.",
keywords = "bladder cancer, cohort studies, diet, epidemiology, nutrients",
author = "Allen, {Naomi E.} and Appleby, {Paul N.} and Key, {Timothy J.} and Bueno-De-Mesquita, {H. B.} and Ros, {Martine M.} and Kiemeney, {Lambertus A L M} and Anne Tj{\o}nneland and Nina Roswall and Kim Overvad and Steffen Weikert and Heiner Boeing and Jenny Chang-Claude and Birgit Teucher and Salvatore Panico and Carlotta Sacerdote and Rosario Tumino and Domenico Palli and Sabina Sieri and Petra Peeters and Quir{\'o}s, {Jose Ram{\'o}n} and Paula Jakszyn and Esther Molina-Montes and Chirlaque, {Mar{\'i}a Dolores} and Eva Ardanaz and Miren Dorronsoro and Khaw, {Kay Tee} and Nick Wareham and B{\"o}rje Ljungberg and G{\"o}ran Hallmans and Roy Ehrnstr{\"o}m and Ulrika Ericson and Gram, {Inger Torhild} and Parr, {Christine L.} and Antonia Trichopoulou and Tina Karapetyan and Vardis Dilis and Fran{\cc}oise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Guy Fagherrazzi and Isabelle Romieu and Gunter, {Marc J.} and Elio Riboli",
year = "2013",
month = "2",
day = "1",
doi = "10.1002/ijc.27643",
language = "English",
volume = "132",
pages = "635--644",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

AU - Allen, Naomi E.

AU - Appleby, Paul N.

AU - Key, Timothy J.

AU - Bueno-De-Mesquita, H. B.

AU - Ros, Martine M.

AU - Kiemeney, Lambertus A L M

AU - Tjønneland, Anne

AU - Roswall, Nina

AU - Overvad, Kim

AU - Weikert, Steffen

AU - Boeing, Heiner

AU - Chang-Claude, Jenny

AU - Teucher, Birgit

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Peeters, Petra

AU - Quirós, Jose Ramón

AU - Jakszyn, Paula

AU - Molina-Montes, Esther

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Ljungberg, Börje

AU - Hallmans, Göran

AU - Ehrnström, Roy

AU - Ericson, Ulrika

AU - Gram, Inger Torhild

AU - Parr, Christine L.

AU - Trichopoulou, Antonia

AU - Karapetyan, Tina

AU - Dilis, Vardis

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Fagherrazzi, Guy

AU - Romieu, Isabelle

AU - Gunter, Marc J.

AU - Riboli, Elio

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3-30%; p trend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36-7%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.

AB - Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3-30%; p trend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36-7%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.

KW - bladder cancer

KW - cohort studies

KW - diet

KW - epidemiology

KW - nutrients

UR - http://www.scopus.com/inward/record.url?scp=84870237118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870237118&partnerID=8YFLogxK

U2 - 10.1002/ijc.27643

DO - 10.1002/ijc.27643

M3 - Article

VL - 132

SP - 635

EP - 644

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -