TY - JOUR
T1 - Macronutrients, energy intake, and breast cancer risk
T2 - Implications from different models
AU - Decarli, Adriano
AU - Favero, Adriano
AU - La Vecchia, Carlo
AU - Russo, Antonio
AU - Ferraroni, Monica
AU - Negri, Eva
AU - Franceschi, Silvia
PY - 1997/7
Y1 - 1997/7
N2 - We used data from a case-control study, conducted in Italy on 2,569 incident cases of breast cancer and 2,588 controls, to fit various energy adjustment models in the estimate of the effect of selected nutrients and alcohol on breast cancer risk. When we fit the standard multivariate and residual models, including total energy intake and the different macronutrients one at a time, the odds ratios (OR) related to 100 kcal per day were 0.90 for protein, 0.96 for saturated fat, 0.88 for unsaturated fat, 0.95 for sugar, 1.07 for starch, and 1.06 for alcohol. When we included all of the different sources of calorie intake in a single model with energy sources partitioned, the OR of adding 100 kcal per day was 0.91 for protein, 1.22 for saturated fat, 0.89 for unsaturated fat, 0.98 for sugar, 1.08 for starch, and 1.07 for alcohol. The estimates from the residual models that included various macronutrients separately were similar to those of the extended energy partition model.
AB - We used data from a case-control study, conducted in Italy on 2,569 incident cases of breast cancer and 2,588 controls, to fit various energy adjustment models in the estimate of the effect of selected nutrients and alcohol on breast cancer risk. When we fit the standard multivariate and residual models, including total energy intake and the different macronutrients one at a time, the odds ratios (OR) related to 100 kcal per day were 0.90 for protein, 0.96 for saturated fat, 0.88 for unsaturated fat, 0.95 for sugar, 1.07 for starch, and 1.06 for alcohol. When we included all of the different sources of calorie intake in a single model with energy sources partitioned, the OR of adding 100 kcal per day was 0.91 for protein, 1.22 for saturated fat, 0.89 for unsaturated fat, 0.98 for sugar, 1.08 for starch, and 1.07 for alcohol. The estimates from the residual models that included various macronutrients separately were similar to those of the extended energy partition model.
KW - Breast neoplasms
KW - Caloric intake
KW - Diet
KW - Dietary carbohydrates
KW - Dietary fats
KW - Dietary protein
KW - Dietary sugar
KW - Epidemiologic methods
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U2 - 10.1097/00001648-199707000-00013
DO - 10.1097/00001648-199707000-00013
M3 - Article
C2 - 9209858
AN - SCOPUS:0030905655
VL - 8
SP - 425
EP - 428
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 4
ER -