Macronutrients, fatty acids and cholesterol intake and stomach cancer risk

E. Lucenteforte, C. Bosetti, S. Gallus, P. Bertuccio, C. Pelucchi, A. Tavani, C. La Vecchia, E. Negri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Several case-control studies have examined the association between intake of selected macronutrients and stomach cancer, with inconsistent results regarding total energy, proteins, carbohydrates and fats. Materials and methods: We considered the relation between total energy, various macronutrients and fatty acids and gastric cancer using data from a case-control study conducted in northern Italy. Cases were 230 patients with incident, histologically confirmed stomach cancer. Controls were 547 frequency-matched patients, admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Logistic regression models conditioned on age and sex and adjusted for selected covariates were used to estimate the odds ratios (ORs) of stomach cancer. Results: The multivariate ORs were 0.65 [95% confidence interval (CI) 0.43-0.98] for the highest versus lowest tertile of vegetable fats and 0.66 (95% CI 0.44-0.97) for polyunsaturated fatty acids. No significant association was found for proteins, sugars, starch, total and animal fats, saturated and monounsaturated fatty acids and cholesterol. Conclusion: In conclusion, our study indicates that selected vegetable fats have a favorable effect on stomach cancer risk.

Original languageEnglish
Pages (from-to)1434-1438
Number of pages5
JournalAnnals of Oncology
Volume20
Issue number8
DOIs
Publication statusPublished - 2009

Keywords

  • Case-control study
  • Diet
  • Dietary fats
  • Stomach cancer

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

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