Macronutrients, fatty acids and cholesterol intake and stomach cancer risk

E. Lucenteforte, C. Bosetti, S. Gallus, P. Bertuccio, C. Pelucchi, A. Tavani, C. La Vecchia, E. Negri

Research output: Contribution to journalArticle

Abstract

Background: Several case-control studies have examined the association between intake of selected macronutrients and stomach cancer, with inconsistent results regarding total energy, proteins, carbohydrates and fats. Materials and methods: We considered the relation between total energy, various macronutrients and fatty acids and gastric cancer using data from a case-control study conducted in northern Italy. Cases were 230 patients with incident, histologically confirmed stomach cancer. Controls were 547 frequency-matched patients, admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Logistic regression models conditioned on age and sex and adjusted for selected covariates were used to estimate the odds ratios (ORs) of stomach cancer. Results: The multivariate ORs were 0.65 [95% confidence interval (CI) 0.43-0.98] for the highest versus lowest tertile of vegetable fats and 0.66 (95% CI 0.44-0.97) for polyunsaturated fatty acids. No significant association was found for proteins, sugars, starch, total and animal fats, saturated and monounsaturated fatty acids and cholesterol. Conclusion: In conclusion, our study indicates that selected vegetable fats have a favorable effect on stomach cancer risk.

Original languageEnglish
Pages (from-to)1434-1438
Number of pages5
JournalAnnals of Oncology
Volume20
Issue number8
DOIs
Publication statusPublished - 2009

Fingerprint

Stomach Neoplasms
Fatty Acids
Cholesterol
Fats
Vegetables
Case-Control Studies
Logistic Models
Odds Ratio
Confidence Intervals
Monounsaturated Fatty Acids
Unsaturated Fatty Acids
Starch
Italy
Proteins
Carbohydrates

Keywords

  • Case-control study
  • Diet
  • Dietary fats
  • Stomach cancer

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

Cite this

Lucenteforte, E., Bosetti, C., Gallus, S., Bertuccio, P., Pelucchi, C., Tavani, A., ... Negri, E. (2009). Macronutrients, fatty acids and cholesterol intake and stomach cancer risk. Annals of Oncology, 20(8), 1434-1438. https://doi.org/10.1093/annonc/mdp009

Macronutrients, fatty acids and cholesterol intake and stomach cancer risk. / Lucenteforte, E.; Bosetti, C.; Gallus, S.; Bertuccio, P.; Pelucchi, C.; Tavani, A.; La Vecchia, C.; Negri, E.

In: Annals of Oncology, Vol. 20, No. 8, 2009, p. 1434-1438.

Research output: Contribution to journalArticle

Lucenteforte, E, Bosetti, C, Gallus, S, Bertuccio, P, Pelucchi, C, Tavani, A, La Vecchia, C & Negri, E 2009, 'Macronutrients, fatty acids and cholesterol intake and stomach cancer risk', Annals of Oncology, vol. 20, no. 8, pp. 1434-1438. https://doi.org/10.1093/annonc/mdp009
Lucenteforte, E. ; Bosetti, C. ; Gallus, S. ; Bertuccio, P. ; Pelucchi, C. ; Tavani, A. ; La Vecchia, C. ; Negri, E. / Macronutrients, fatty acids and cholesterol intake and stomach cancer risk. In: Annals of Oncology. 2009 ; Vol. 20, No. 8. pp. 1434-1438.
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