Macronutrients, fatty acids, cholesterol, and risk of benign prostatic hyperplasia

Francesca Bravi, Cristina Bosetti, Luigino Dal Maso, Renato Talamini, Maurizio Montella, Eva Negri, Valerio Ramazzotti, Silvia Franceschi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Objectives: To better understand the role of specific macronutrients on the risk of benign prostatic hyperplasia (BPH), we used data from an Italian case-control study. Although BPH is extremely common among the elderly, its etiology-and, particularly, the role of diet and specific macronutrients-is still unclear. Methods: A case-control study of 1369 patients with BPH and 1451 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, was conducted in Italy. The subjects' usual diet was investigated through a validated and reproducible food frequency questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were obtained after allowance for energy intake and other potential confounding factors. Results: A significant direct relation was observed between starch intake (OR 1.51, 95% CI 1.15 to 1.99 for highest quintile compared with lowest one), and an inverse relation was observed for polyunsaturated fatty acids (OR 0.72, 95% CI 0.55 to 0.93), linoleic acid (OR 0.73, 95% CI 0.56 to 0.94), and linolenic acid (OR 0.71, 95% CI 0.54 to 0.93). Conclusions: The results of this study suggest a role for specific macronutrients in the risk of BPH, including, in particular, an unfavorable effect for starch and a beneficial one for polyunsaturated fatty acids.

Original languageEnglish
Pages (from-to)1205-1211
Number of pages7
Issue number6
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Urology


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