Abstract
Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.
| Original language | English |
|---|---|
| Pages (from-to) | 14-20 |
| Number of pages | 7 |
| Journal | Immunity |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 17 2014 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
Macrophage Activation and Polarization : Nomenclature and Experimental Guidelines. / Murray, Peter J.; Allen, Judith E.; Biswas, Subhra K.; Fisher, Edward A.; Gilroy, Derek W.; Goerdt, Sergij; Gordon, Siamon; Hamilton, John A.; Ivashkiv, Lionel B.; Lawrence, Toby; Locati, Massimo; Mantovani, Alberto; Martinez, Fernando O.; Mege, Jean Louis; Mosser, David M.; Natoli, Gioacchino; Saeij, Jeroen P.; Schultze, Joachim L.; Shirey, KariAnn; Sica, Antonio; Suttles, Jill; Udalova, Irina; vanGinderachter, Jo A.; Vogel, Stefanie N.; Wynn, Thomas A.
In: Immunity, Vol. 41, No. 1, 17.07.2014, p. 14-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macrophage Activation and Polarization
T2 - Nomenclature and Experimental Guidelines
AU - Murray, Peter J.
AU - Allen, Judith E.
AU - Biswas, Subhra K.
AU - Fisher, Edward A.
AU - Gilroy, Derek W.
AU - Goerdt, Sergij
AU - Gordon, Siamon
AU - Hamilton, John A.
AU - Ivashkiv, Lionel B.
AU - Lawrence, Toby
AU - Locati, Massimo
AU - Mantovani, Alberto
AU - Martinez, Fernando O.
AU - Mege, Jean Louis
AU - Mosser, David M.
AU - Natoli, Gioacchino
AU - Saeij, Jeroen P.
AU - Schultze, Joachim L.
AU - Shirey, KariAnn
AU - Sica, Antonio
AU - Suttles, Jill
AU - Udalova, Irina
AU - vanGinderachter, Jo A.
AU - Vogel, Stefanie N.
AU - Wynn, Thomas A.
PY - 2014/7/17
Y1 - 2014/7/17
N2 - Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.
AB - Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.
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UR - http://www.scopus.com/inward/citedby.url?scp=84904394690&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2014.06.008
DO - 10.1016/j.immuni.2014.06.008
M3 - Article
C2 - 25035950
AN - SCOPUS:84904394690
VL - 41
SP - 14
EP - 20
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 1
ER -