Macrophage activation in human brucellosis

E. Magliulo, G. Carosi, D. F. Scevola, G. Filice, I. Saladino

Research output: Contribution to journalArticle

Abstract

This report deals with some ultrastructural and functional changes which were observed in human monocytes from peripheral blood in patients treated with Brucella vaccine during the remittance phase of an acute B. melitensis infection. Monocytes from these patients showed increased "in vitro" phagocytic and bactericidal activities and displayed morphological attributes which are considered characteristic of the so-called macrophage activation, a functional modification observed solely in animals in association with cell-mediated immunity states. The authors discuss their findings in relation to previous results obtained in human tuberculin hypersensitivity and put forward the hypothesis that the observed modifications in morphology and function of monocytes might be obtained through release by sensitized lymphocytes of lymphokine factors acting on mononuclear phagocytes.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalInfection
Volume1
Issue number3
DOIs
Publication statusPublished - Sep 1973

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Brucellosis
Macrophage Activation
Monocytes
Brucella Vaccine
Lymphokines
Tuberculin
Phagocytes
Cellular Immunity
Hypersensitivity
Economics
Lymphocytes
Infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Magliulo, E., Carosi, G., Scevola, D. F., Filice, G., & Saladino, I. (1973). Macrophage activation in human brucellosis. Infection, 1(3), 144-150. https://doi.org/10.1007/BF01641324

Macrophage activation in human brucellosis. / Magliulo, E.; Carosi, G.; Scevola, D. F.; Filice, G.; Saladino, I.

In: Infection, Vol. 1, No. 3, 09.1973, p. 144-150.

Research output: Contribution to journalArticle

Magliulo, E, Carosi, G, Scevola, DF, Filice, G & Saladino, I 1973, 'Macrophage activation in human brucellosis', Infection, vol. 1, no. 3, pp. 144-150. https://doi.org/10.1007/BF01641324
Magliulo E, Carosi G, Scevola DF, Filice G, Saladino I. Macrophage activation in human brucellosis. Infection. 1973 Sep;1(3):144-150. https://doi.org/10.1007/BF01641324
Magliulo, E. ; Carosi, G. ; Scevola, D. F. ; Filice, G. ; Saladino, I. / Macrophage activation in human brucellosis. In: Infection. 1973 ; Vol. 1, No. 3. pp. 144-150.
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