Abstract
This report deals with some ultrastructural and functional changes which were observed in human monocytes from peripheral blood in patients treated with Brucella vaccine during the remittance phase of an acute B. melitensis infection. Monocytes from these patients showed increased "in vitro" phagocytic and bactericidal activities and displayed morphological attributes which are considered characteristic of the so-called macrophage activation, a functional modification observed solely in animals in association with cell-mediated immunity states. The authors discuss their findings in relation to previous results obtained in human tuberculin hypersensitivity and put forward the hypothesis that the observed modifications in morphology and function of monocytes might be obtained through release by sensitized lymphocytes of lymphokine factors acting on mononuclear phagocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 144-150 |
| Number of pages | 7 |
| Journal | Infection |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1973 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Immunology
Cite this
Macrophage activation in human brucellosis. / Magliulo, E.; Carosi, G.; Scevola, D. F.; Filice, G.; Saladino, I.
In: Infection, Vol. 1, No. 3, 09.1973, p. 144-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macrophage activation in human brucellosis
AU - Magliulo, E.
AU - Carosi, G.
AU - Scevola, D. F.
AU - Filice, G.
AU - Saladino, I.
PY - 1973/9
Y1 - 1973/9
N2 - This report deals with some ultrastructural and functional changes which were observed in human monocytes from peripheral blood in patients treated with Brucella vaccine during the remittance phase of an acute B. melitensis infection. Monocytes from these patients showed increased "in vitro" phagocytic and bactericidal activities and displayed morphological attributes which are considered characteristic of the so-called macrophage activation, a functional modification observed solely in animals in association with cell-mediated immunity states. The authors discuss their findings in relation to previous results obtained in human tuberculin hypersensitivity and put forward the hypothesis that the observed modifications in morphology and function of monocytes might be obtained through release by sensitized lymphocytes of lymphokine factors acting on mononuclear phagocytes.
AB - This report deals with some ultrastructural and functional changes which were observed in human monocytes from peripheral blood in patients treated with Brucella vaccine during the remittance phase of an acute B. melitensis infection. Monocytes from these patients showed increased "in vitro" phagocytic and bactericidal activities and displayed morphological attributes which are considered characteristic of the so-called macrophage activation, a functional modification observed solely in animals in association with cell-mediated immunity states. The authors discuss their findings in relation to previous results obtained in human tuberculin hypersensitivity and put forward the hypothesis that the observed modifications in morphology and function of monocytes might be obtained through release by sensitized lymphocytes of lymphokine factors acting on mononuclear phagocytes.
UR - http://www.scopus.com/inward/record.url?scp=0015751446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015751446&partnerID=8YFLogxK
U2 - 10.1007/BF01641324
DO - 10.1007/BF01641324
M3 - Article
C2 - 4597097
AN - SCOPUS:0015751446
VL - 1
SP - 144
EP - 150
JO - Infection
JF - Infection
SN - 0300-8126
IS - 3
ER -