Macrophage activation syndrome induced by A/H1N1 influenza in cystic fibrosis

Rosaria Casciaro, Federico Cresta, Federica Favilli, Aldo Naselli, Alessandra De Alessandri, Laura Minicucci

Research output: Contribution to journalArticlepeer-review


Bacterial respiratory infections have an important impact on the development and progression of pulmonary disease in cystic fibrosis (CF). Viral infections are possible triggers of acute deterioration in the clinical status of CF patients. Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease characterized by pancytopenia, hepatitis, hyperferritinemia, coagulopathy, and neurologic symptoms. This syndrome is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction. Here, we report the case of a boy affected by CF who developed MAS triggered by pandemic H1N1 influenza; good clinical response was obtained through high dose prednisone treatment. Pediatr Pulmonol. 2014; 49:E10-E12.

Original languageEnglish
JournalPediatric Pulmonology
Issue number2
Publication statusPublished - Feb 2014


  • cystic fibrosis
  • H1N1
  • MAS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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