Macrophage fusion cuisine

Antonio Sica; Alberto Mantovani

doi:10.1182/blood-2009-09-242800

Macrophage fusion cuisine

Antonio Sica, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.¹ This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

Original language	English
Pages (from-to)	4609-4610
Number of pages	2
Journal	Blood
Volume	114
Issue number	21
DOIs	https://doi.org/10.1182/blood-2009-09-242800
Publication status	Published - Nov 19 2009

ASJC Scopus subject areas

Biochemistry
Cell Biology
Immunology
Hematology

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abstract = "In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.",

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