Macrophage fusion cuisine

Antonio Sica; Alberto Mantovani

doi:10.1182/blood-2009-09-242800

Macrophage fusion cuisine

Antonio Sica, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.¹ This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

Original language	English
Pages (from-to)	4609-4610
Number of pages	2
Journal	Blood
Volume	114
Issue number	21
DOIs	https://doi.org/10.1182/blood-2009-09-242800
Publication status	Published - Nov 19 2009

ASJC Scopus subject areas

Biochemistry
Cell Biology
Immunology
Hematology

Access to Document

10.1182/blood-2009-09-242800

Cite this

@article{97e237ebe34f4afa83f983703eb0e8d6,

title = "Macrophage fusion cuisine",

abstract = "In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.",

author = "Antonio Sica and Alberto Mantovani",

year = "2009",

month = nov,

day = "19",

doi = "10.1182/blood-2009-09-242800",

language = "English",

volume = "114",

pages = "4609--4610",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "21",

}

TY - JOUR

T1 - Macrophage fusion cuisine

AU - Sica, Antonio

AU - Mantovani, Alberto

PY - 2009/11/19

Y1 - 2009/11/19

N2 - In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

AB - In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

UR - http://www.scopus.com/inward/record.url?scp=77950397414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950397414&partnerID=8YFLogxK

U2 - 10.1182/blood-2009-09-242800

DO - 10.1182/blood-2009-09-242800

M3 - Article

C2 - 19965712

AN - SCOPUS:77950397414

VL - 114

SP - 4609

EP - 4610

JO - Blood

JF - Blood

SN - 0006-4971

IS - 21

ER -

Macrophage fusion cuisine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this