Macrophage fusion cuisine

Antonio Sica, Alberto Mantovani

Research output: Contribution to journal › Article

Abstract

In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

Original languageEnglish
Pages (from-to)4609-4610
Number of pages2
JournalBlood
Volume114
Issue number21
DOIs
Publication statusPublished - Nov 19 2009

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Macrophages
Cadherins
Fusion reactions
Catenins
Polyamines
Interleukin-4
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Hematology

Cite this

Macrophage fusion cuisine. / Sica, Antonio; Mantovani, Alberto.

In: Blood, Vol. 114, No. 21, 19.11.2009, p. 4609-4610.

Research output: Contribution to journal › Article

Sica, A & Mantovani, A 2009, 'Macrophage fusion cuisine', Blood, vol. 114, no. 21, pp. 4609-4610. https://doi.org/10.1182/blood-2009-09-242800
Sica A, Mantovani A. Macrophage fusion cuisine. Blood. 2009 Nov 19;114(21):4609-4610. https://doi.org/10.1182/blood-2009-09-242800
Sica, Antonio ; Mantovani, Alberto. / Macrophage fusion cuisine. In: Blood. 2009 ; Vol. 114, No. 21. pp. 4609-4610.
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