Abstract
In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.
Original language | English |
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Pages (from-to) | 4609-4610 |
Number of pages | 2 |
Journal | Blood |
Volume | 114 |
Issue number | 21 |
DOIs | |
Publication status | Published - Nov 19 2009 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Immunology
- Hematology