Macrophage heterogeneity in the context of rheumatoid arthritis

Irina A. Udalova, Alberto Mantovani, Marc Feldmann

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies.

Original languageEnglish
Pages (from-to)472-485
Number of pages14
JournalNature Reviews Rheumatology
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Rheumatoid Arthritis
Macrophages
Phenotype
Synovial Membrane
Rheumatic Diseases
Arthritis
Monocytes
Anti-Inflammatory Agents
Joints
Therapeutics
Research
Population

ASJC Scopus subject areas

  • Rheumatology

Cite this

Macrophage heterogeneity in the context of rheumatoid arthritis. / Udalova, Irina A.; Mantovani, Alberto; Feldmann, Marc.

In: Nature Reviews Rheumatology, Vol. 12, No. 8, 01.08.2016, p. 472-485.

Research output: Contribution to journalReview article

Udalova, Irina A. ; Mantovani, Alberto ; Feldmann, Marc. / Macrophage heterogeneity in the context of rheumatoid arthritis. In: Nature Reviews Rheumatology. 2016 ; Vol. 12, No. 8. pp. 472-485.
@article{966f1b995e0d4bc4b94cbb8c3a218e88,
title = "Macrophage heterogeneity in the context of rheumatoid arthritis",
abstract = "Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies.",
author = "Udalova, {Irina A.} and Alberto Mantovani and Marc Feldmann",
year = "2016",
month = "8",
day = "1",
doi = "10.1038/nrrheum.2016.91",
language = "English",
volume = "12",
pages = "472--485",
journal = "Nature reviews. Rheumatology",
issn = "1759-4790",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Macrophage heterogeneity in the context of rheumatoid arthritis

AU - Udalova, Irina A.

AU - Mantovani, Alberto

AU - Feldmann, Marc

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies.

AB - Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies.

UR - http://www.scopus.com/inward/record.url?scp=84978062481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978062481&partnerID=8YFLogxK

U2 - 10.1038/nrrheum.2016.91

DO - 10.1038/nrrheum.2016.91

M3 - Review article

VL - 12

SP - 472

EP - 485

JO - Nature reviews. Rheumatology

JF - Nature reviews. Rheumatology

SN - 1759-4790

IS - 8

ER -