Macrophage infiltrate and prognosis in c-erbB-2-overexpressing breast carcinomas

S. M. Pupa, R. Bufalino, A. M. Invernizzi, S. Andreola, F. Rilke, L. Lombardi, M. I. Colnaghi, S. Ménard

Research output: Contribution to journalArticle

Abstract

Purpose: Experiments were designed to investigate the association between tumor leukocytic infiltrates with other pathologic and biologic variables in primary tumors and with prognosis, and to define the phenotype of the infiltrating leukocytes. Patients and Methods: A retrospective series of 1,207 primary breast carcinomas was studied according to different prognostic variables, including the presence of lymphoplasmacytic infiltrate (LPI). LPI was analyzed in association with other variables and survival. Additionally, a small prospective series of surgical specimens from 75 primary breast carcinomas with infiltrating leukocytes was tested by immunohistochemistry an frozen sections to phenotypically characterize the infiltrate, using anti-CD reagents, and the tumor, using anti-c-erbB-2 oncoprotein monoclonal antibody. Results: In the retrospective series, menopausal status, nodal status, tumor size, stage, grade, and p 185(HER2) overexpression but not LPI were found to be associated with prognosis and maintained their prognostic significance in a multivariate analysis. LPI was significantly associated with some of these independent prognostic factors, such as tumor size (P = .03), stage (P = .004), grade III carcinomas (P <.000001), and overexpression of the p185(HER2) (P <.000001). In some subgroups of patients in whom LPI was found more frequently, such as grade III cases or N- and c-erbB-2-positive cases, LPI was found to be indicative of a good prognosis (P = .008 and P = .03, respectively). Phenotypic analysis of the infiltrating leukocytes revealed a preponderance of macrophages in high-grade (P = .05) or c-erbB-2-positive (P = .008) tumors, whereas T cells constituted most of the infiltrate in the other tumors. Conclusion: Our data demonstrate different leukocytic types in the infiltrate of breast tumors with different prognostic significance.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalJournal of Clinical Oncology
Volume14
Issue number1
Publication statusPublished - Jan 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Pupa, S. M., Bufalino, R., Invernizzi, A. M., Andreola, S., Rilke, F., Lombardi, L., Colnaghi, M. I., & Ménard, S. (1996). Macrophage infiltrate and prognosis in c-erbB-2-overexpressing breast carcinomas. Journal of Clinical Oncology, 14(1), 85-94.