Macrophage-mediated cytostatic activity on tumour cells after treatment with Triton WR 1339

Alberto Mantovani, Nadia Polentarutti, Marina Sironi, Annunciata Vecchi, Federico Spreafico, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Peritoneal macrophages collected from mice treated with schedules of Triton WR 1339 previously shown to inhibit metastasis formation in experimental tumour models were found to nonspecifically inhibit growth and DNA synthesis of tumour cells in vitro. No significant lysis of51Cr-labelled target cells could de detected. It is suggested that activation of macrophage-mediated cytostasis may contribute to the antimetastatic activity of Triton WR 1339.

Original languageEnglish
JournalEuropean Journal of Cancer (1965)
Volume14
Issue number3
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Oncology

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