Abstract
In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.
Original language | English |
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Pages (from-to) | 653-654 |
Number of pages | 2 |
Journal | Cell Metabolism |
Volume | 24 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 8 2016 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology