Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani; Massimo Locati

doi:10.1016/j.cmet.2016.10.016

Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani, Massimo Locati

Istituto Clinico Humanitas

Research output: Contribution to journal › Short survey › peer-review

Abstract

In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

Original language	English
Pages (from-to)	653-654
Number of pages	2
Journal	Cell Metabolism
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2016.10.016
Publication status	Published - Nov 8 2016

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2016.10.016

Cite this

@article{36820975ed83467da4f02fe71e902f6e,

title = "Macrophage Metabolism Shapes Angiogenesis in Tumors",

abstract = "In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.",

author = "Alberto Mantovani and Massimo Locati",

year = "2016",

month = nov,

day = "8",

doi = "10.1016/j.cmet.2016.10.016",

language = "English",

volume = "24",

pages = "653--654",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Macrophage Metabolism Shapes Angiogenesis in Tumors

AU - Mantovani, Alberto

AU - Locati, Massimo

PY - 2016/11/8

Y1 - 2016/11/8

N2 - In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

AB - In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

UR - http://www.scopus.com/inward/record.url?scp=84994631052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994631052&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2016.10.016

DO - 10.1016/j.cmet.2016.10.016

M3 - Short survey

AN - SCOPUS:84994631052

VL - 24

SP - 653

EP - 654

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 5

ER -

Macrophage Metabolism Shapes Angiogenesis in Tumors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this