Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani; Massimo Locati

doi:10.1016/j.cmet.2016.10.016

Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani, Massimo Locati

Istituto Clinico Humanitas

Research output: Contribution to journal › Short survey › peer-review

Abstract

In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

Original language	English
Pages (from-to)	653-654
Number of pages	2
Journal	Cell Metabolism
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2016.10.016
Publication status	Published - Nov 8 2016

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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title = "Macrophage Metabolism Shapes Angiogenesis in Tumors",

abstract = "In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.",

author = "Alberto Mantovani and Massimo Locati",

year = "2016",

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AU - Locati, Massimo

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AB - In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

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SN - 1550-4131

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Macrophage Metabolism Shapes Angiogenesis in Tumors

Abstract

ASJC Scopus subject areas

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