Macrophage Metabolism Shapes Angiogenesis in Tumors

Research output: Contribution to journalShort surveypeer-review

Abstract

In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

Original languageEnglish
Pages (from-to)653-654
Number of pages2
JournalCell Metabolism
Volume24
Issue number5
DOIs
Publication statusPublished - Nov 8 2016

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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