Macrophage plasticity and polarization in tissue repair and remodelling

Alberto Mantovani, Subhra K. Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati

Research output: Contribution to journalArticlepeer-review

Abstract

Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2-like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation.

Original languageEnglish
Pages (from-to)176-185
Number of pages10
JournalJournal of Pathology
Volume229
Issue number2
DOIs
Publication statusPublished - Jan 2013

Keywords

  • activation
  • healing
  • macrophage
  • polarization
  • resolution
  • tissue remodelling
  • tissue repair

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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