Macrophage polarization in tumour progression

Antonio Sica, Paola Larghi, Alessandra Mancino, Luca Rubino, Chiara Porta, Maria Grazia Totaro, Monica Rimoldi, Subhra Kumar Biswas, Paola Allavena, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and immunosuppression. This paradoxical role of macrophages in cancer finds an explanation in their functional plasticity, that may result in the polarized expression of either pro- or anti-tumoural functions. Key players in the setting of their phenotype are the microenvironmental signals to which macrophages are exposed, which selectively tune their functions within a functional spectrum encompassing the M1 and M2 extremes. Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalSeminars in Cancer Biology
Volume18
Issue number5
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Cancer
  • Innate immunity
  • Polarized inflammation
  • Tumour-associated macrophages

ASJC Scopus subject areas

  • Cancer Research

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