Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by β-haematin (malaria pigment)

Fausta Omodeo-Salè, Nicoletta Basilico, Marco Folini, Piero Olliaro, Donatella Taramelli

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the susceptibility of peritoneal mouse macrophages and macrophage and microglia cell lines to the peroxidative activity of β-haematin, the synthetic polymer identical to native malaria pigment. The extent of lipid peroxidation, measured as production of thiobarbituric acid reactive substances (TBARS), was greater for peritoneal macrophages than for cell lines and microligia cells. TBARS production apparently was not attributable to the release of free iron from the protoporphyrin moiety, but related to lower glutathione content and different lipid composition of the cell membrane. These findings offer a new interpretation for the contentious immunomodulatory effects of β-haematin reported for phagocytes of different origins.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalFEBS Letters
Volume433
Issue number3
Publication statusPublished - Aug 21 1998

Keywords

  • βHematin
  • Lipid peroxidation
  • Machrophage
  • Malaria pigment

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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