Macrophages in cancer and infectious diseases: The 'good' and the 'bad'

Chiara Porta, Elena Riboldi, Maria Grazia Totaro, Laura Strauss, Antonio Sica, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.

Original languageEnglish
Pages (from-to)1185-1202
Number of pages18
JournalImmunotherapy
Volume3
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • cancer-related inflammation
  • chemokines
  • HIV-1
  • macrophages
  • Mycobacterium tuberculosis
  • parasites infections
  • polarized inflammation
  • Tie2-expressing monocytes
  • tumor-associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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