Macrophages in multiple myeloma

Domenico Ribatti, Michele Moschetta, Angelo Vacca

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor associated macrophages (TAMs) are a rich source of pro-angiogenic cytokines and growth factors, and a relationship between the TAMs content, the rate of tumor growth and the extent of vascularization has been shown in several tumors. In this article, we have summarized the literature and our data concerning the involvement of TAMs in angiogenesis occurring in multiple myeloma. Finally, therapeutic aspects concerning the potential role of molecules which inhibit macrophage recruitment in the tumor side are also discussed.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalImmunology Letters
Volume161
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Angiogenesis
  • Anti-angiogenesis
  • Inflammation
  • Macrophages
  • Multiple myeloma

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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