Macrophages in rheumatoid arthritis

N. Maruotti, F. P. Cantatore, E. Crivellato, A. Vacca, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


In rheumatoid arthritis (RA) tissue macrophages release growth factors, matrix metalloproteinases, cytokines, and chemokines. While in normal joints there is a balance between proinflammatory and anti-inflammatory cytokines, an imbalance between these inducers and inhibitors of inflammation occurs in RA, where macrophages are responsible for inducing inflammation, matrix destruction and angiogenesis.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalHistology and Histopathology
Issue number4-6
Publication statusPublished - Apr 2007


  • Chemokine
  • Cytokine
  • Macrophage
  • Metalloproteinase
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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