Abstract
Smouldering inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation. Tumor-associated macrophages orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; cell growth; angiogenesis; matrix deposition and remodelling; the construction of a metastatic niche and actual metastasis; response to hormones and chemotherapeutic agents.T and B cells or cancer cell-derived signals orchestrate the functional reprogramming of TAM. In general TAM acquire M2-like properties and resemble 'tolerant' macrophages, though there is diversity in pathways and phenotypes in different tumors. TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression.
| Original language | English |
|---|---|
| Pages (from-to) | 231-237 |
| Number of pages | 7 |
| Journal | Current Opinion in Immunology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2010 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Macrophages, innate immunity and cancer : balance, tolerance, and diversity. / Mantovani, Alberto; Sica, Antonio.
In: Current Opinion in Immunology, Vol. 22, No. 2, 04.2010, p. 231-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macrophages, innate immunity and cancer
T2 - balance, tolerance, and diversity
AU - Mantovani, Alberto
AU - Sica, Antonio
PY - 2010/4
Y1 - 2010/4
N2 - Smouldering inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation. Tumor-associated macrophages orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; cell growth; angiogenesis; matrix deposition and remodelling; the construction of a metastatic niche and actual metastasis; response to hormones and chemotherapeutic agents.T and B cells or cancer cell-derived signals orchestrate the functional reprogramming of TAM. In general TAM acquire M2-like properties and resemble 'tolerant' macrophages, though there is diversity in pathways and phenotypes in different tumors. TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression.
AB - Smouldering inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation. Tumor-associated macrophages orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; cell growth; angiogenesis; matrix deposition and remodelling; the construction of a metastatic niche and actual metastasis; response to hormones and chemotherapeutic agents.T and B cells or cancer cell-derived signals orchestrate the functional reprogramming of TAM. In general TAM acquire M2-like properties and resemble 'tolerant' macrophages, though there is diversity in pathways and phenotypes in different tumors. TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression.
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UR - http://www.scopus.com/inward/citedby.url?scp=77950944395&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2010.01.009
DO - 10.1016/j.coi.2010.01.009
M3 - Article
C2 - 20144856
AN - SCOPUS:77950944395
VL - 22
SP - 231
EP - 237
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 2
ER -