Macrophages, innate immunity and cancer: balance, tolerance, and diversity

Research output: Contribution to journalArticle

828 Citations (Scopus)

Abstract

Smouldering inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation. Tumor-associated macrophages orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; cell growth; angiogenesis; matrix deposition and remodelling; the construction of a metastatic niche and actual metastasis; response to hormones and chemotherapeutic agents.T and B cells or cancer cell-derived signals orchestrate the functional reprogramming of TAM. In general TAM acquire M2-like properties and resemble 'tolerant' macrophages, though there is diversity in pathways and phenotypes in different tumors. TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalCurrent Opinion in Immunology
Volume22
Issue number2
DOIs
Publication statusPublished - Apr 2010

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Innate Immunity
Macrophages
Neoplasms
Inflammation
Tumor Microenvironment
Growth
B-Lymphocytes
Hormones
Neoplasm Metastasis
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Macrophages, innate immunity and cancer : balance, tolerance, and diversity. / Mantovani, Alberto; Sica, Antonio.

In: Current Opinion in Immunology, Vol. 22, No. 2, 04.2010, p. 231-237.

Research output: Contribution to journalArticle

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