Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema

Umberto De Benedetto, Giuseppe Querques, Rosangela Lattanzio, Enrico Borrelli, Giacinto Triolo, Gisella Maestranzi, Giliola Calori, Lea Querques, Francesco Bandello

Research output: Contribution to journalArticle

Abstract

PURPOSE:: To study retinal function in asymptomatic Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS:: Thirty-six consecutive Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS:: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabetic patients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabetic patients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabetic patients, respectively; it was statistically different compared with control groups (P <0.0001 and P <0.0001, respectively). CONCLUSION:: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabetic patients. Central foveal thickness was increased in all diabetic patients compared with healthy controls, despite the absence of diabetic macular edema.

Original languageEnglish
Pages (from-to)2171-2177
Number of pages7
JournalRetina
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 12 2014

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Macular Edema
Diabetic Retinopathy
Control Groups
Optical Coherence Tomography
Type 2 Diabetes Mellitus
Visual Acuity

Keywords

  • diabetes
  • macular edema
  • microperimetry
  • nonproliferative
  • optical coherence tomography
  • retinopathy
  • Type 1
  • Type 2

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

De Benedetto, U., Querques, G., Lattanzio, R., Borrelli, E., Triolo, G., Maestranzi, G., ... Bandello, F. (2014). Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema. Retina, 34(11), 2171-2177. https://doi.org/10.1097/IAE.0000000000000205

Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema. / De Benedetto, Umberto; Querques, Giuseppe; Lattanzio, Rosangela; Borrelli, Enrico; Triolo, Giacinto; Maestranzi, Gisella; Calori, Giliola; Querques, Lea; Bandello, Francesco.

In: Retina, Vol. 34, No. 11, 12.11.2014, p. 2171-2177.

Research output: Contribution to journalArticle

De Benedetto, U, Querques, G, Lattanzio, R, Borrelli, E, Triolo, G, Maestranzi, G, Calori, G, Querques, L & Bandello, F 2014, 'Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema', Retina, vol. 34, no. 11, pp. 2171-2177. https://doi.org/10.1097/IAE.0000000000000205
De Benedetto U, Querques G, Lattanzio R, Borrelli E, Triolo G, Maestranzi G et al. Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema. Retina. 2014 Nov 12;34(11):2171-2177. https://doi.org/10.1097/IAE.0000000000000205
De Benedetto, Umberto ; Querques, Giuseppe ; Lattanzio, Rosangela ; Borrelli, Enrico ; Triolo, Giacinto ; Maestranzi, Gisella ; Calori, Giliola ; Querques, Lea ; Bandello, Francesco. / Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema. In: Retina. 2014 ; Vol. 34, No. 11. pp. 2171-2177.
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AU - De Benedetto, Umberto

AU - Querques, Giuseppe

AU - Lattanzio, Rosangela

AU - Borrelli, Enrico

AU - Triolo, Giacinto

AU - Maestranzi, Gisella

AU - Calori, Giliola

AU - Querques, Lea

AU - Bandello, Francesco

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N2 - PURPOSE:: To study retinal function in asymptomatic Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS:: Thirty-six consecutive Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS:: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabetic patients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabetic patients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabetic patients, respectively; it was statistically different compared with control groups (P <0.0001 and P <0.0001, respectively). CONCLUSION:: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabetic patients. Central foveal thickness was increased in all diabetic patients compared with healthy controls, despite the absence of diabetic macular edema.

AB - PURPOSE:: To study retinal function in asymptomatic Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS:: Thirty-six consecutive Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS:: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabetic patients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabetic patients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabetic patients, respectively; it was statistically different compared with control groups (P <0.0001 and P <0.0001, respectively). CONCLUSION:: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabetic patients. Central foveal thickness was increased in all diabetic patients compared with healthy controls, despite the absence of diabetic macular edema.

KW - diabetes

KW - macular edema

KW - microperimetry

KW - nonproliferative

KW - optical coherence tomography

KW - retinopathy

KW - Type 1

KW - Type 2

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