Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema

Umberto De Benedetto, Giuseppe Querques, Rosangela Lattanzio, Enrico Borrelli, Giacinto Triolo, Gisella Maestranzi, Giliola Calori, Lea Querques, Francesco Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE:: To study retinal function in asymptomatic Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS:: Thirty-six consecutive Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS:: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabetic patients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabetic patients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabetic patients, respectively; it was statistically different compared with control groups (P <0.0001 and P <0.0001, respectively). CONCLUSION:: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabetic patients. Central foveal thickness was increased in all diabetic patients compared with healthy controls, despite the absence of diabetic macular edema.

Original languageEnglish
Pages (from-to)2171-2177
Number of pages7
JournalRetina
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 12 2014

Keywords

  • diabetes
  • macular edema
  • microperimetry
  • nonproliferative
  • optical coherence tomography
  • retinopathy
  • Type 1
  • Type 2

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema'. Together they form a unique fingerprint.

Cite this