Abstract
Steady-state macular (9° × 9°) electroretinograms in response to either sinusoidal flicker (focal electroretinogram) or counterphased sinusoidal gratings (pattern electroretinogram) were recorded in 14 patients with inner lamellar macular holes, in 4 patients with full-thickness macular holes and in 14 age-matched controls. Fourier analysis of focal and pattern electroretinograms yielded three main components: a first and a second harmonic to flicker, and a second harmonic to pattern. Recent evidence indicates that the first harmonic to flicker is of receptoral origin, whereas the flicker and pattern second harmonics represent, at least in part, the activity of different generators in the inner retina. When compared to controls, patients with inner lamellar holes showed significant amplitude reduction and phase delay for both flicker and pattern second harmonics, but not for the flicker first harmonic. Patients with full-thickness holes showed significant amplitude reduction also for the flicker first harmonic. These results indicate a prevalent functional involvement of the inner retina in lamellar macular holes, which can be clinically detected by evaluating focal and pattern electroretinogram second harmonics.
| Original language | English |
|---|---|
| Pages (from-to) | 99-108 |
| Number of pages | 10 |
| Journal | Documenta Ophthalmologica |
| Volume | 79 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1992 |
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Keywords
- Focal electroretinogram
- lamellar macular holes
- pattern electroretinogram
- steadystate analysis
ASJC Scopus subject areas
- Ophthalmology
Cite this
Macular electroretinograms to flicker and pattern stimulation in lamellar macular holes. / Falsini, Benedetto; Minnella, Angelo; Buzzonetti, Luca; Merendino, Erasmo; Porciatti, Vittorio.
In: Documenta Ophthalmologica, Vol. 79, No. 2, 06.1992, p. 99-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macular electroretinograms to flicker and pattern stimulation in lamellar macular holes
AU - Falsini, Benedetto
AU - Minnella, Angelo
AU - Buzzonetti, Luca
AU - Merendino, Erasmo
AU - Porciatti, Vittorio
PY - 1992/6
Y1 - 1992/6
N2 - Steady-state macular (9° × 9°) electroretinograms in response to either sinusoidal flicker (focal electroretinogram) or counterphased sinusoidal gratings (pattern electroretinogram) were recorded in 14 patients with inner lamellar macular holes, in 4 patients with full-thickness macular holes and in 14 age-matched controls. Fourier analysis of focal and pattern electroretinograms yielded three main components: a first and a second harmonic to flicker, and a second harmonic to pattern. Recent evidence indicates that the first harmonic to flicker is of receptoral origin, whereas the flicker and pattern second harmonics represent, at least in part, the activity of different generators in the inner retina. When compared to controls, patients with inner lamellar holes showed significant amplitude reduction and phase delay for both flicker and pattern second harmonics, but not for the flicker first harmonic. Patients with full-thickness holes showed significant amplitude reduction also for the flicker first harmonic. These results indicate a prevalent functional involvement of the inner retina in lamellar macular holes, which can be clinically detected by evaluating focal and pattern electroretinogram second harmonics.
AB - Steady-state macular (9° × 9°) electroretinograms in response to either sinusoidal flicker (focal electroretinogram) or counterphased sinusoidal gratings (pattern electroretinogram) were recorded in 14 patients with inner lamellar macular holes, in 4 patients with full-thickness macular holes and in 14 age-matched controls. Fourier analysis of focal and pattern electroretinograms yielded three main components: a first and a second harmonic to flicker, and a second harmonic to pattern. Recent evidence indicates that the first harmonic to flicker is of receptoral origin, whereas the flicker and pattern second harmonics represent, at least in part, the activity of different generators in the inner retina. When compared to controls, patients with inner lamellar holes showed significant amplitude reduction and phase delay for both flicker and pattern second harmonics, but not for the flicker first harmonic. Patients with full-thickness holes showed significant amplitude reduction also for the flicker first harmonic. These results indicate a prevalent functional involvement of the inner retina in lamellar macular holes, which can be clinically detected by evaluating focal and pattern electroretinogram second harmonics.
KW - Focal electroretinogram
KW - lamellar macular holes
KW - pattern electroretinogram
KW - steadystate analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=0026522212&partnerID=8YFLogxK
U2 - 10.1007/BF00156569
DO - 10.1007/BF00156569
M3 - Article
VL - 79
SP - 99
EP - 108
JO - Documenta Ophthalmologica
JF - Documenta Ophthalmologica
SN - 0012-4486
IS - 2
ER -