Macular function in eyes with open-angle glaucoma evaluated by multifocal electroretinogram

Vincenzo Parisi, Lucia Ziccardi, Marco Centofanti, Lucia Tanga, Geltrude Gallinaro, Benedetto Falsini, Massimo G. Bucci

Research output: Contribution to journalArticlepeer-review


PURPOSE. To evaluate macular function in patients with openangle glaucoma (OAG) by means of multifocal electroretinogram (mfERG). METHODS. Twenty-four OAG patients (mean age 54.6 6 9.1 years) and 14 age-similar controls were enrolled. OAG patients had intraocular pressure (IOP) less than 18 mm Hg with topical medical treatment, 24-2 visual field (Humphrey Field Analyzer [HFA]) with mean deviation (MD) between-2 and-12 dB, and corrected pattern standard deviation (CPSD) between {thorn}2 and +10 dB and no history or presence of cataract and/or macular disease. MfERGs in response to 61 M-stimuli presented to the central 208 of the visual field were assessed in OAG patients (24 eyes) and in controls (14 eyes). Ring (R) analysis was performed every five retinal eccentricities in areas between the fovea and midperiphery: 0° to 2.5° (R1), 2.5° to 5° (R2), 5° to 10° (R3), 10° to 15° (R4), and 15° to 20° (R5). MfERG response amplitude density of the N1-P1 components (N1-P1 RAD, nV/deg2) and P1 implicit time (P1 IT, ms) of the firstorder binary kernel were measured for each ring. RESULTS. OAGpatients showed a significant (P

Original languageEnglish
Pages (from-to)6973-6980
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Issue number11
Publication statusPublished - Oct 2012

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)


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