Macular hole closure patterns: an updated classification

Tommaso Rossi, Daniela Bacherini, Tomaso Caporossi, Serena Telani, Danilo Iannetta, Stanislao Rizzo, Stavros N. Moysidis, Nicole Koulisis, Tamer H. Mahmoud, Guido Ripandelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The classification of macular hole closure patterns (MHCPs) currently relies on time domain OCT allowing only “open” and “closed” statuses or is based on inner foveal contour shape. Both classification types give no information on retinal layer reconstitution. Novel sophisticated surgical techniques lead to previously unknown MHCPs, outdating existing classifications and urging new ones. The purpose of the present study is to introduce a new classification allowing proper description of all MHCPs resulting from newer surgeries and based on the restoration of retinal layers. Methods: Retrospective analysis of patients undergoing MH surgery with five different surgical techniques was performed. MHCPs were classified according to spectral domain optical coherence tomography (SD-OCT). Type 0: open MH (0A: flat margin, 0B: elevated, 0C: oedematous); type 1: closed MHs (1A: reconstitution all retinal layers; 1B interruption of the external layers; 1C interruption of internal layers); type 2: MH closed with autologous or heterologous filling tissue interrupting the normal foveal layered anatomy (2A: filling tissue through all layers; 2B reconstitution of normal inner retinal layers; 2C reconstitution of normal outer retinal layers; 2D H-shaped bridging of filling tissue). Results: Closure rate was 95.2% (241/253). Surgical technique and vision correlated to closure pattern (p <0.001). Type 1 MHCPs had the best post-operative visual acuity (VA) compared with type 2 and type 0 (p <0.001). MHCPs 1A and 1C performed better than all others. MHCP at months 1 and 3 changed in 42/254 (16.5%) and remained stable in 212/254 (83.5%). Improvement in vision was higher in eyes with shifting closure pattern (0.57 ± 0.33 vs 0.51 ± 0.48 logMAR; p 0.021). Conclusion: MHCP classification based on retinal layer restoration properly comprises post-operative anatomic morphologies. MHCPs correlate the surgical technique and post-operative visual outcomes. [Figure not available: see fulltext.]
Original languageEnglish
Pages (from-to)2629-2638
Number of pages10
JournalGraefe's Arch. Clin. Exp. Ophthalmol.
Volume258
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Amniotic membrane implant
  • Autologous retina implant
  • Autologous retinal transplantation
  • Closure pattern
  • Graft
  • Human amniotic membrane
  • Internal limiting membrane
  • Macular hole
  • Pars plana vitrectomy

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