Macular microcysts in mitochondrial optic neuropathies

Prevalence and retinal layer thickness measurements

Michele Carbonelli, Chiara La Morgia, Giacomo Savini, Maria Lucia Cascavilla, Enrico Borrelli, Filipe Chicani, Carolina Do V F Ramos, Solange R. Salomao, Vincenzo Parisi, Jerry Sebag, Francesco Bandello, Alfredo A. Sadun, Valerio Carelli, Piero Barboni

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). Methods: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections. Results: MM were identified in 5/90 (5.6%) patients with LHON and 3/58 (5.2%) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p

Original languageEnglish
Article numbere0127906
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 5 2015

Fingerprint

Optic Nerve Diseases
Thickness measurement
peripheral nervous system diseases
optics
Optics
Autosomal Dominant Optic Atrophy
Leber's Hereditary Optic Atrophy
atrophy
Optical Coherence Tomography
Nerve Fibers
Optical tomography
tomography
nerve fibers
Visual Acuity
Analysis of variance (ANOVA)
Analysis of Variance
Software
analysis of variance
Control Groups
Fibers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Macular microcysts in mitochondrial optic neuropathies : Prevalence and retinal layer thickness measurements. / Carbonelli, Michele; La Morgia, Chiara; Savini, Giacomo; Cascavilla, Maria Lucia; Borrelli, Enrico; Chicani, Filipe; Ramos, Carolina Do V F; Salomao, Solange R.; Parisi, Vincenzo; Sebag, Jerry; Bandello, Francesco; Sadun, Alfredo A.; Carelli, Valerio; Barboni, Piero.

In: PLoS One, Vol. 10, No. 6, e0127906, 05.06.2015.

Research output: Contribution to journalArticle

Carbonelli, M, La Morgia, C, Savini, G, Cascavilla, ML, Borrelli, E, Chicani, F, Ramos, CDVF, Salomao, SR, Parisi, V, Sebag, J, Bandello, F, Sadun, AA, Carelli, V & Barboni, P 2015, 'Macular microcysts in mitochondrial optic neuropathies: Prevalence and retinal layer thickness measurements', PLoS One, vol. 10, no. 6, e0127906. https://doi.org/10.1371/journal.pone.0127906
Carbonelli, Michele ; La Morgia, Chiara ; Savini, Giacomo ; Cascavilla, Maria Lucia ; Borrelli, Enrico ; Chicani, Filipe ; Ramos, Carolina Do V F ; Salomao, Solange R. ; Parisi, Vincenzo ; Sebag, Jerry ; Bandello, Francesco ; Sadun, Alfredo A. ; Carelli, Valerio ; Barboni, Piero. / Macular microcysts in mitochondrial optic neuropathies : Prevalence and retinal layer thickness measurements. In: PLoS One. 2015 ; Vol. 10, No. 6.
@article{d4e65eb8ac0d4133944643ad1bf18d7e,
title = "Macular microcysts in mitochondrial optic neuropathies: Prevalence and retinal layer thickness measurements",
abstract = "Purpose: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). Methods: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections. Results: MM were identified in 5/90 (5.6{\%}) patients with LHON and 3/58 (5.2{\%}) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p",
author = "Michele Carbonelli and {La Morgia}, Chiara and Giacomo Savini and Cascavilla, {Maria Lucia} and Enrico Borrelli and Filipe Chicani and Ramos, {Carolina Do V F} and Salomao, {Solange R.} and Vincenzo Parisi and Jerry Sebag and Francesco Bandello and Sadun, {Alfredo A.} and Valerio Carelli and Piero Barboni",
year = "2015",
month = "6",
day = "5",
doi = "10.1371/journal.pone.0127906",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Macular microcysts in mitochondrial optic neuropathies

T2 - Prevalence and retinal layer thickness measurements

AU - Carbonelli, Michele

AU - La Morgia, Chiara

AU - Savini, Giacomo

AU - Cascavilla, Maria Lucia

AU - Borrelli, Enrico

AU - Chicani, Filipe

AU - Ramos, Carolina Do V F

AU - Salomao, Solange R.

AU - Parisi, Vincenzo

AU - Sebag, Jerry

AU - Bandello, Francesco

AU - Sadun, Alfredo A.

AU - Carelli, Valerio

AU - Barboni, Piero

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Purpose: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). Methods: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections. Results: MM were identified in 5/90 (5.6%) patients with LHON and 3/58 (5.2%) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p

AB - Purpose: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). Methods: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections. Results: MM were identified in 5/90 (5.6%) patients with LHON and 3/58 (5.2%) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p

UR - http://www.scopus.com/inward/record.url?scp=84934963841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934963841&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0127906

DO - 10.1371/journal.pone.0127906

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e0127906

ER -