Macular microcysts in mitochondrial optic neuropathies: Prevalence and retinal layer thickness measurements

Michele Carbonelli, Chiara La Morgia, Giacomo Savini, Maria Lucia Cascavilla, Enrico Borrelli, Filipe Chicani, Carolina Do V F Ramos, Solange R. Salomao, Vincenzo Parisi, Jerry Sebag, Francesco Bandello, Alfredo A. Sadun, Valerio Carelli, Piero Barboni

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). Methods: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections. Results: MM were identified in 5/90 (5.6%) patients with LHON and 3/58 (5.2%) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p

Original languageEnglish
Article numbere0127906
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 5 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Carbonelli, M., La Morgia, C., Savini, G., Cascavilla, M. L., Borrelli, E., Chicani, F., Ramos, C. D. V. F., Salomao, S. R., Parisi, V., Sebag, J., Bandello, F., Sadun, A. A., Carelli, V., & Barboni, P. (2015). Macular microcysts in mitochondrial optic neuropathies: Prevalence and retinal layer thickness measurements. PLoS One, 10(6), [e0127906]. https://doi.org/10.1371/journal.pone.0127906