Abstract
Aims To evaluate longitudinal retinal ganglion cell inner plexiform layer (GC-IPL) and macular retinal nerve fibre layer (mRNFL) thickness changes in acute Leber's hereditary optic neuropathy (LHON). Methods: Six eyes of four patients with LHON underwent SD-OCT (optical coherence tomography) at month 1, 3, 6 and 12 after visual loss. In two eyes, the examination was carried out in the presymptomatic stage. The relationship and curves for area under the receiver operator characteristic (AUROC) were generated to assess the ability of each parameter to detect ganglion cell loss. Results: Significant longitudinal thinning of GC-IPL and mRNFL was detected in LHON. GC-IPL thinning was detectable in the deviation map during the presymptomatic stage in the inner ring of the nasal sector and then it progressively extended following a centrifugal and spiral pattern. Similarly, mRNFL thinning began in the inferonasal sector and it progressively extended. No further statistically significant changes were detected after month 3. The highest level of AUROC values at 1 month were detected in the nasal sectors and inferonasal mRNFL thickness reached AUROC value=1. All the parameters were equally able to detect ganglion cell loss from month 2 to 12. Conclusions: The natural history of GC-IPL thinning follows a specific pattern of reduction, reflecting the anatomical course of papillomacular fibres. Month 6 represents the end of GC-IPL loss. GC-IPL and mRNFL thinning is detectable before onset of visual loss. These observations can help future therapeutic approaches for both LHON carriers at high risk of conversion and patients with acute early LHON.
| Original language | English |
|---|---|
| Pages (from-to) | 1232-1237 |
| Number of pages | 6 |
| Journal | British Journal of Ophthalmology |
| Volume | 100 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2016 |
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Keywords
- Genetics
- Optic Nerve
ASJC Scopus subject areas
- Medicine(all)
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Macular nerve fibre and ganglion cell layer changes in acute Leber's hereditary optic neuropathy. / Balducci, Nicole; Savini, Giacomo; Cascavilla, Maria L.; La Morgia, Chiara; Triolo, Giacinto; Giglio, Rosa; Carbonelli, Michele; Parisi, Vincenzo; Sadun, Alfredo Arrigo; Bandello, Francesco; Carelli, Valerio; Barboni, Piero.
In: British Journal of Ophthalmology, Vol. 100, No. 9, 01.09.2016, p. 1232-1237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macular nerve fibre and ganglion cell layer changes in acute Leber's hereditary optic neuropathy
AU - Balducci, Nicole
AU - Savini, Giacomo
AU - Cascavilla, Maria L.
AU - La Morgia, Chiara
AU - Triolo, Giacinto
AU - Giglio, Rosa
AU - Carbonelli, Michele
AU - Parisi, Vincenzo
AU - Sadun, Alfredo Arrigo
AU - Bandello, Francesco
AU - Carelli, Valerio
AU - Barboni, Piero
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (La Morgia Chiara, Carelli Valerio)
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Aims To evaluate longitudinal retinal ganglion cell inner plexiform layer (GC-IPL) and macular retinal nerve fibre layer (mRNFL) thickness changes in acute Leber's hereditary optic neuropathy (LHON). Methods: Six eyes of four patients with LHON underwent SD-OCT (optical coherence tomography) at month 1, 3, 6 and 12 after visual loss. In two eyes, the examination was carried out in the presymptomatic stage. The relationship and curves for area under the receiver operator characteristic (AUROC) were generated to assess the ability of each parameter to detect ganglion cell loss. Results: Significant longitudinal thinning of GC-IPL and mRNFL was detected in LHON. GC-IPL thinning was detectable in the deviation map during the presymptomatic stage in the inner ring of the nasal sector and then it progressively extended following a centrifugal and spiral pattern. Similarly, mRNFL thinning began in the inferonasal sector and it progressively extended. No further statistically significant changes were detected after month 3. The highest level of AUROC values at 1 month were detected in the nasal sectors and inferonasal mRNFL thickness reached AUROC value=1. All the parameters were equally able to detect ganglion cell loss from month 2 to 12. Conclusions: The natural history of GC-IPL thinning follows a specific pattern of reduction, reflecting the anatomical course of papillomacular fibres. Month 6 represents the end of GC-IPL loss. GC-IPL and mRNFL thinning is detectable before onset of visual loss. These observations can help future therapeutic approaches for both LHON carriers at high risk of conversion and patients with acute early LHON.
AB - Aims To evaluate longitudinal retinal ganglion cell inner plexiform layer (GC-IPL) and macular retinal nerve fibre layer (mRNFL) thickness changes in acute Leber's hereditary optic neuropathy (LHON). Methods: Six eyes of four patients with LHON underwent SD-OCT (optical coherence tomography) at month 1, 3, 6 and 12 after visual loss. In two eyes, the examination was carried out in the presymptomatic stage. The relationship and curves for area under the receiver operator characteristic (AUROC) were generated to assess the ability of each parameter to detect ganglion cell loss. Results: Significant longitudinal thinning of GC-IPL and mRNFL was detected in LHON. GC-IPL thinning was detectable in the deviation map during the presymptomatic stage in the inner ring of the nasal sector and then it progressively extended following a centrifugal and spiral pattern. Similarly, mRNFL thinning began in the inferonasal sector and it progressively extended. No further statistically significant changes were detected after month 3. The highest level of AUROC values at 1 month were detected in the nasal sectors and inferonasal mRNFL thickness reached AUROC value=1. All the parameters were equally able to detect ganglion cell loss from month 2 to 12. Conclusions: The natural history of GC-IPL thinning follows a specific pattern of reduction, reflecting the anatomical course of papillomacular fibres. Month 6 represents the end of GC-IPL loss. GC-IPL and mRNFL thinning is detectable before onset of visual loss. These observations can help future therapeutic approaches for both LHON carriers at high risk of conversion and patients with acute early LHON.
KW - Genetics
KW - Optic Nerve
UR - http://www.scopus.com/inward/record.url?scp=84985986798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84985986798&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2015-307326
DO - 10.1136/bjophthalmol-2015-307326
M3 - Article
C2 - PMID: 26614631
VL - 100
SP - 1232
EP - 1237
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 9
ER -