Macular sensitivity change in multiple sclerosis followed with microperimetry

Mario R. Romano, M. Angi, F. Romano

Research output: Contribution to journalArticlepeer-review


PURPOSE. To describe the efficacy of MP-1 in detecting early multiple sclerosis (MS) retinal lesions and in monitoring the effectiveness of treatment in terms of changes in macular sensitivity. METHODS. A 21-year-old woman with MS was referred to us complaining of recurrent episodes of eyesight loss in both eyes. At ophthalmologic examination, best-corrected visual acuity was 20/25 bilaterally; ophthalmoscopy showed bilateral slight optic neuritis without swelling of the disc. Static perimetry of central visual field (30 degrees, by Octopus 101, Haag-Streit AG, Switzerland) and retinal sensitivity of the 12 central degrees (by MP-1 Micro Perimeter, Nidek Inc., Italy) were performed on the patient at that time. The microperimeter (MP-1) showed a loss of sensitivity in the macular region with 0.28±0.9 dB sensitivity in the right eye and 19.42±1.5 dB in the left. The mean fixation stability was 91% considering 2° and 99% considering 4° around the fixation points in the right eye, and 97% in 2° and 100% in 4° central degrees in the left. In the weeks that followed vision continued to get worse in both eyes, so she underwent a steroid therapy with methylprednisolone IV 1000 mg/day for 5 days and 500 mg/day for 3 days. RESULTS. After 8 days of therapy the MP-1 showed a significant recovery in the right eye, with mean light sensitivity being 19.61±1.3 dB in the right eye and 20.0±0 dB in the left eye in both macular and peripapillary regions. The mean fixation stability was 100% considering 2° and 100% considering 4° around the fixation points in both eyes. CONLCUSIONS. The MP-1 can be an interesting tool for neuro-ophthalmologists as it allows a more precise evaluation of the macular and peripapillary region, which is not easily studied with conventional automated perimetry. In MS, the presence of a subclinical form of optic nerve involvement can be demonstrated in a very early stage, and well followed by the introduction of microperimeter testing in the standard examination protocol.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalEuropean Journal of Ophthalmology
Issue number3
Publication statusPublished - May 2007


  • Changes in macular sensitivity
  • Microperimetry
  • MP-1
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ophthalmology

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