Abstract
Purpose To describe the efficacy of microperimetry (MP-1) in detecting early retinal toxicity as a result of chronic use of chloroquine and in monitoring the changes in macular sensitivity in an asymptomatic patient with best-corrected visual acuity of 20/20 bilaterally. Methods A 60-year-old woman presented for routine ocular examination with a medical history of severe rheumatoid arthritis, for which she had been receiving 3 mg chloroquine (CQ) per kilogram for the past 17 years. The patient was asymptomatic with best-corrected visual acuity of 20/20 bilaterally. Results Microperimeter showed loss of sensitivity in the macular region with a dense scotoma within the central 12 degrees (2.80 ± 4.7 dB right eye and 2.84 ± 4.7 dB left eye). CQ treatment was discontinued and substituted by Plaquenil. Conclusions Chloroquine retinal toxicity can be recognized in a subclincal form by the presence of early changes in macular sensitivity, detected by MP-1.
Original language | English |
---|---|
Pages (from-to) | 195-197 |
Number of pages | 3 |
Journal | International Ophthalmology |
Volume | 30 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2010 |
Keywords
- Chloroquine retinopathy
- Early detection
- Macular sensitivity
- Microperimetry
ASJC Scopus subject areas
- Ophthalmology