MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation

Clara Rizzardi, Lucio Torelli, Manuela Schneider, Fabiola Giudici, Lorenzo Zandona, Matteo Biasotto, Roberto Di Lenarda, Mauro Melato

Research output: Contribution to journalArticle

Abstract

Background: Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated. Materials and Methods: We analyzed the expression of MAD2 in 49 cases of oral squamous cell carcinoma by immunohistochemistry and compared the findings with clinicopathological parameters, proliferative activity, BUBR1 expression and DNA ploidy. Results: MAD2 was over-expressed in 18 (36.7%) cases. Tumors with overexpression of MAD2 were associated with the progression of histological grade from well to poor differentiation (p

Original languageEnglish
Pages (from-to)7021-7027
Number of pages7
JournalAnticancer Research
Volume34
Issue number12
Publication statusPublished - Dec 1 2014

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Keywords

  • BUBR1.
  • MAD2
  • Oral
  • Prognostic factor
  • Spindle checkpoint
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Rizzardi, C., Torelli, L., Schneider, M., Giudici, F., Zandona, L., Biasotto, M., Di Lenarda, R., & Melato, M. (2014). MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation. Anticancer Research, 34(12), 7021-7027.