MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation

Clara Rizzardi; Lucio Torelli; Manuela Schneider; Fabiola Giudici; Lorenzo Zandona; Matteo Biasotto; Roberto Di Lenarda; Mauro Melato

MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation

Clara Rizzardi, Lucio Torelli, Manuela Schneider, Fabiola Giudici, Lorenzo Zandona, Matteo Biasotto, Roberto Di Lenarda, Mauro Melato

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article

Abstract

Background: Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated. Materials and Methods: We analyzed the expression of MAD2 in 49 cases of oral squamous cell carcinoma by immunohistochemistry and compared the findings with clinicopathological parameters, proliferative activity, BUBR1 expression and DNA ploidy. Results: MAD2 was over-expressed in 18 (36.7%) cases. Tumors with overexpression of MAD2 were associated with the progression of histological grade from well to poor differentiation (p

Original language	English
Pages (from-to)	7021-7027
Number of pages	7
Journal	Anticancer Research
Volume	34
Issue number	12
Publication status	Published - Dec 1 2014

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Keywords

BUBR1.
MAD2
Oral
Prognostic factor
Spindle checkpoint
Squamous cell carcinoma

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

Cite this

Rizzardi, C., Torelli, L., Schneider, M., Giudici, F., Zandona, L., Biasotto, M., Di Lenarda, R., & Melato, M. (2014). MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation. Anticancer Research, 34(12), 7021-7027.

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abstract = "Background: Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated. Materials and Methods: We analyzed the expression of MAD2 in 49 cases of oral squamous cell carcinoma by immunohistochemistry and compared the findings with clinicopathological parameters, proliferative activity, BUBR1 expression and DNA ploidy. Results: MAD2 was over-expressed in 18 (36.7%) cases. Tumors with overexpression of MAD2 were associated with the progression of histological grade from well to poor differentiation (p",

keywords = "BUBR1., MAD2, Oral, Prognostic factor, Spindle checkpoint, Squamous cell carcinoma",

author = "Clara Rizzardi and Lucio Torelli and Manuela Schneider and Fabiola Giudici and Lorenzo Zandona and Matteo Biasotto and {Di Lenarda}, Roberto and Mauro Melato",

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T1 - MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation

AU - Rizzardi, Clara

AU - Torelli, Lucio

AU - Schneider, Manuela

AU - Giudici, Fabiola

AU - Zandona, Lorenzo

AU - Biasotto, Matteo

AU - Di Lenarda, Roberto

AU - Melato, Mauro

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background: Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated. Materials and Methods: We analyzed the expression of MAD2 in 49 cases of oral squamous cell carcinoma by immunohistochemistry and compared the findings with clinicopathological parameters, proliferative activity, BUBR1 expression and DNA ploidy. Results: MAD2 was over-expressed in 18 (36.7%) cases. Tumors with overexpression of MAD2 were associated with the progression of histological grade from well to poor differentiation (p

AB - Background: Defects in the cell-cycle surveillance mechanism, called the spindle checkpoint, might contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma. MAD2 and BUBR1 are key components of the spindle checkpoint, whose role in oral carcinogenesis and clinical relevance still need to be elucidated. Materials and Methods: We analyzed the expression of MAD2 in 49 cases of oral squamous cell carcinoma by immunohistochemistry and compared the findings with clinicopathological parameters, proliferative activity, BUBR1 expression and DNA ploidy. Results: MAD2 was over-expressed in 18 (36.7%) cases. Tumors with overexpression of MAD2 were associated with the progression of histological grade from well to poor differentiation (p

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KW - MAD2

KW - Oral

KW - Prognostic factor

KW - Spindle checkpoint

KW - Squamous cell carcinoma

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MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation

Abstract

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Keywords

ASJC Scopus subject areas

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