Madin Darby Canine Kidney: A new cell line for Pneumocystis capinii in vitro culture

C. Atzori, A. Bruno, C. Agostoni, S. Novati, S. Gatti, M. Scaglia

Research output: Contribution to journalArticlepeer-review

Abstract

Pneumocystis carinii pneumonia (PCP) is a highly frequent cause of morbidity and mortality in immunocompromised subjects, particularly in HIV-infected ones. The biology of P. carinii is poorly understood because of the lack of reiable synthetic media or adequate cell lines to grow this opportunistic pathogen in continuous culture. We reported the suitability of the MDCK (Madin Darby Canine Kidney, ATTC CCL 34) cell line to support the temporary microorganism's growth in vitro and the experimental pharmacological trials, in comparison with the HEL 299 cell line, used as reference standard.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalParasite (Paris, France)
Volume3
Issue number2
Publication statusPublished - 1996

Keywords

  • In vitro culture
  • MDCK cell line
  • Pneumocystis carinii

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology

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